ArticleJournal of Korean medical science2012
Association between toll-like receptors/CD14 gene polymorphisms and inflammatory bowel disease in Korean population.
Article in Journal of Korean medical science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 6 of them syntheses that pooled it.
What it found
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Who cites it
20 citing papers in PubMed, 6 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Correlations between TLR polymorphisms and inflammatory bowel disease: a meta-analysis of 49 case-control studies.Immunologic research · 2019Pooled it
- Association between TLR2 and TLR4 Gene Polymorphisms and the Susceptibility to Inflammatory Bowel Disease: A Meta-Analysis.PloS one · 2015Pooled it
- Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis.BMC gastroenterology · 2014Pooled it
- The association between C-159T polymorphism in CD14 gene and susceptibility to tuberculosis: a meta-analysis.Molecular biology reports · 2014Pooled it
- Interleukin and interleukin receptor gene polymorphisms in inflammatory bowel diseases susceptibility.World journal of gastroenterology · 2014Pooled it
- Association between CD14 gene C-260T polymorphism and inflammatory bowel disease: a meta-analysis.PloS one · 2012Pooled it
- Serum levels of Wnt5a in Egyptian women with obesity and their association with toll like receptor 2 Arg753Gln gene polymorphism in a pilot case control study of obesity as a state of metaflammation.Scientific reports · 2025Article
- The Association of TLR2, TLR3, and TLR9 Gene Polymorphisms With Susceptibility to Talaromycosis Among Han Chinese AIDS Patients in Guangdong.Frontiers in cellular and infection microbiology · 2021Article
- Genetics of ulcerative colitis: putting into perspective the incremental gains from Indian studies.Journal of genetics · 2018Review
- Article
- Genetic Diversity of CD14 Promoter Gene Polymorphism (Infectious diseases · 2017Article
- Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy.World journal of gastroenterology · 2016Observational
- Transcription Factor SP2 Enhanced the Expression of Cd14 in Colitis-Susceptible C3H/HeJBir.PloS one · 2016Article
- Association of TLR5 gene polymorphisms in ulcerative colitis patients of north India and their role in cytokine homeostasis.PloS one · 2015Article
- VKORC1 and CD-14 genetic polymorphisms associate with susceptibility to cardiovascular and cerebrovascular diseases.International journal of clinical and experimental medicine · 2015Article
- The association of polymorphisms of TLR4 and CD14 genes with susceptibility to sepsis in a Chinese population.BMC medical genetics · 2014Article
- Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature.World journal of gastrointestinal pathophysiology · 2014Review
- Article
- Helicobacter pylori Infection Enhances Gastric Mucosal Inflammation in Individuals Carrying the 260-T Allele of the CD14 Gene.Gut and liver · 2013Article
- Toll-like receptors and human disease: lessons from single nucleotide polymorphisms.Current genomics · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The innate immune response in patients who develop inflammatory bowel disease (IBD) may be abnormal. However, the exact role of Toll-like receptors (TLRs) / CD14 gene in the pathogenesis of IBD has not been fully elucidated. We aimed to investigate the association between polymorphisms of TLR1, 2, 4, 6, and CD14 gene and susceptibility to IBD in Korean population. A total 144 patients of IBD (99 patients with ulcerative colitis, 45 patients with Crohn's disease) and 178 healthy controls were enrolled. Using a PCR-RFLP, we evaluated mutations of TLR1 (Arg80Thr), TLR2 (Arg753Gln and Arg677Trp), TLR4 (Asp299Gly and Thr399Ile), TLR6 (Ser249Pro) genes and the -159 C/T promoter polymorphism of CD14 gene. No TLR polymorphisms were detected in Korean subjects. T allele and TT genotype frequencies of CD14 gene were significantly higher in IBD patients than in healthy controls. In subgroup analysis, T allelic frequency was higher in pancolitis phenotype of ulcerative colitis. In Korean population, the promoter polymorphism at -159 C/T of the CD14 gene is positively associated with IBD, both ulcerative colitis and Crohn's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.