ArticleWorld journal of gastroenterology2011
Human papillomavirus in upper digestive tract tumors from three countries.
Article in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- HPV prevalence in esophageal cancer: an updated systematic review and meta-analysis.Frontiers in microbiology · 2026Pooled it
- Mucosal alpha-papillomaviruses are not associated with esophageal squamous cell carcinomas: Lack of mechanistic evidence from South Africa, China and Iran and from a world-wide meta-analysis.International journal of cancer · 2016Pooled it
- The role of human papillomavirus in oral squamous cell carcinoma: myth and reality.Oral and maxillofacial surgery · 2014Pooled it
- Prevalence of human papillomavirus among oesophageal squamous cell carcinoma cases: systematic review and meta-analysis.British journal of cancer · 2014Pooled it
- Human papillomavirus prevalence in oral and oropharyngeal squamous cell carcinoma in South America: A systematic review and meta-analysis.Oncology reviews · 2022Article
- Human papillomavirus-16 infection and p16 expression in oral squamous cell carcinoma.Oncology letters · 2021Article
- Association of viral load and physical status of HPV-16 with survival of patients with head and neck cancer.Ecancermedicalscience · 2020Article
- HPV33+ HNSCC is associated with poor prognosis and has unique genomic and immunologic landscapes.Oral oncology · 2020Article
- Effect of vaccination against oral HPV-16 infection in high school students in the city of Cali, Colombia.Papillomavirus research (Amsterdam, Netherlands) · 2019Article
- Human Papillomavirus Type 16 Integration Analysis by Real-time PCR Assay in Associated Cancers.Translational oncology · 2018Article
- Human papillomavirus genome variants and head and neck cancers: a perspective.Infectious agents and cancer · 2018Review
- Detection of human papillomavirus-16 DNA in archived clinical samples of breast and lung cancer patients from North Pakistan.Journal of cancer research and clinical oncology · 2016Article
- p53 expression but not p16(INK4A) correlates with human papillomavirus-associated esophageal squamous cell carcinoma in Kazakh population.Infectious agents and cancer · 2016Article
- Viruses, Other Pathogenic Microorganisms and Esophageal Cancer.Gastrointestinal tumors · 2015Review
- A systems biology analysis of the changes in gene expression via silencing of HPV-18 E1 expression in HeLa cells.Open biology · 2014Article
- Inhibitors of differentiation-1 promotes nitrosopyrrolidine-induced transformation of HPV 16-immortalized cervical epithelial cell.Cancer science · 2014Article
- Human papillomavirus (HPV) status of non-tobacco related squamous cell carcinomas of the lateral tongue.Oral oncology · 2014Article
- Human papillomavirus detection in head and neck squamous cell carcinoma.Ecancermedicalscience · 2014Article
- Impact of HPV infection on the development of head and neck cancer.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Review
- P16 and P53 Expression in Esophageal Squamous Cell Carcinoma: A Brief Report From The Experience of South of Iran, and Review of the Literature.Clinical pathology (Thousand Oaks, Ventura County, Calif.)Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo clarify human papillomavirus (HPV) involvement in carcinogenesis of the upper digestive tract of virological and pathological analyses.
methodsThe present study examined the presence of HPV in squamous cell carcinomas of the oral cavity (n = 71), and esophagus (n = 166) collected from Japan, Pakistan and Colombia, with different HPV exposure risk and genetic backgrounds. The viral load and physical status of HPV16 and HPV16-E6 variants were examined. Comparison of p53 and p16(INK4a) expression in HPV-positive and HPV-negative cases was also made.
resultsHPV16 was found in 39 (55%) oral carcinomas (OCs) and 24 (14%) esophageal carcinomas (ECs). This site-specific difference in HPV detection between OCs and ECs was statistically significant (P < 0.001). There was a significant difference in the geographical distribution of HPV16-E6 variants. Multiple infections of different HPV types were found in 13 ECs, but multiple infections were not found in OCs. This difference was statistically significant (P = 0.001). The geometric means (95% confidence interval) of HPV16 viral load in OCs and ECs were 0.06 (0.02-0.18) and 0.12 (0.05-0.27) copies per cell, respectively. The expression of p16(INK4a) proteins was increased by the presence of HPV in ECs (53% and 33% in HPV-positive and -negative ECs, respectively; P = 0.036), and the high-risk type of the HPV genome was not detected in surrounding normal esophageal mucosa of HPV-positive ECs.
conclusionBased on our results, we cannot deny the possibility of HPV16 involvement in the carcinogenesis of the esophagus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.