ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2012
Proteomic screening of glycoproteins in human plasma for frailty biomarkers.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Cerebrospinal fluid proteomic profile of frailty: Results from the PROLIPHYC cohort.Aging cell · 2024Article
- What If the Clinical and Older Adults' Perspectives about Frailty Converge? A Call for a Mixed Conceptual Model of Frailty: A Traditional Literature Review.Healthcare (Basel, Switzerland) · 2023Review
- Circulating H-FABP as a biomarker of frailty in patients with chronic heart failure.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Potential therapeutic targets for sarcopenia identified by Mendelian randomisation.Age and ageing · 2023Article
- Article
- Frailty and Biological Age.Annals of geriatric medicine and research · 2021Article
- Characterization of the plasma proteomic profile of frailty phenotype.GeroScience · 2021Article
- Frailty subtypes and recovery in older survivors of acute respiratory failure: a pilot study.Thorax · 2021Article
- Blood Nanoparticles - Influence on Extracellular Vesicle Isolation and Characterization.Frontiers in pharmacology · 2021Review
- Plasma proteomic profile of frailty.Aging cell · 2020Article
- Frailty biomarkers in humans and rodents: Current approaches and future advances.Mechanisms of ageing and development · 2019Review
- Review of Interventions for the Frailty Syndrome and the Role of Metformin as a Potential Pharmacologic Agent for Frailty Prevention.Clinical therapeutics · 2019Review
- Current and emerging biomarkers of frailty in the elderly.Clinical interventions in aging · 2019Review
- Article
- Identification of Pre-frailty Sub-Phenotypes in Elderly Using Metabolomics.Frontiers in physiology · 2018Article
- Senescent cells expose and secrete an oxidized form of membrane-bound vimentin as revealed by a natural polyreactive antibody.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Increased levels of hyper-stable protein aggregates in plasma of older adults.Age (Dordrecht, Netherlands) · 2016Article
- Integrated glycoprotein immobilization method for glycopeptide and glycan analysis of cardiac hypertrophy.Analytical chemistry · 2015Article
- Plasma protein biomarkers of the geriatric syndrome of frailty.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The application of proteomics methodology for analyzing human blood samples is of increasing importance as a noninvasive method for understanding, detecting, and monitoring disease. In particular, glycoproteomic analysis may be useful in the study of age-related diseases and syndromes, such as frailty. This study demonstrates the use of methodology for isolating plasma glycoproteins using lectins, comparing the glycoproteome by frailty status using two-dimensional polyacrylamide gel electrophoresis and identifying glycoproteins using mass spectrometry. In a pilot study, we found seven glycoproteins to differ by at least twofold in prefrail compared with nonfrail older adults, including haptoglobin, transferrin, and fibrinogen, consistent with known inflammatory and hematologic changes associated with frailty. Enzyme-linked immunosorbent assay analysis found that plasma transferrin concentration was increased in frail and prefrail older adults compared with nonfrail, confirming our proteomic findings. This work provides evidence for using a reproducible methodology for conducting clinical proteomic comparative studies of age-related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.