ArticleJournal of the Royal Society, Interface2012
Computational modelling of cell chain migration reveals mechanisms that sustain follow-the-leader behaviour.
Article in Journal of the Royal Society, Interface, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- A Comparison of Mechanisms Driving Lesion Outcomes During Lung Tumor and Tuberculosis Granuloma Formation.Bulletin of mathematical biology · 2026Article
- Internal cohesion gradient as a novel mechanism of collective cell migration.PLoS computational biology · 2025Article
- A biased random walk approach for modeling the collective chemotaxis of neural crest cells.Journal of mathematical biology · 2024Article
- Agent-based modeling of morphogenetic systems: Advantages and challenges.PLoS computational biology · 2019Review
- Neural crest and cancer: Divergent travelers on similar paths.Mechanisms of development · 2017Review
- Vertebrate Axial Patterning: From Egg to Asymmetry.Advances in experimental medicine and biology · 2017Review
- Leaders in collective migration: are front cells really endowed with a particular set of skills?F1000Research · 2017Review
- Modelling collective cell migration of neural crest.Current opinion in cell biology · 2016Review
- Multidisciplinary approaches to understanding collective cell migration in developmental biology.Open biology · 2016Review
- Cells as strain-cued automata.Journal of the mechanics and physics of solids · 2016Article
- Physiological electrical signals promote chain migration of neuroblasts by up-regulating P2Y1 purinergic receptors and enhancing cell adhesion.Stem cell reviews and reports · 2015Article
- Simulating cancer growth with multiscale agent-based modeling.Seminars in cancer biology · 2015Review
- Investigation of the essential role of platelet-tumor cell interactions in metastasis progression using an agent-based model.Theoretical biology & medical modelling · 2014Article
- Article
- Unraveling intestinal stem cell behavior with models of crypt dynamics.Integrative biology : quantitative biosciences from nano to macro · 2014Review
- Article
- Do pioneer cells exist?PloS one · 2014Article
- Simple rules for a "simple" nervous system? Molecular and biomathematical approaches to enteric nervous system formation and malformation.Developmental biology · 2013Review
- Follow-the-leader cell migration requires biased cell-cell contact and local microenvironmental signals.Physical biology · 2013Article
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Authors and funding
3 authors.
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Abstract
Follow-the-leader chain migration is a striking cell migratory behaviour observed during vertebrate development, adult neurogenesis and cancer metastasis. Although cell-cell contact and extracellular matrix (ECM) cues have been proposed to promote this phenomenon, mechanisms that underlie chain migration persistence remain unclear. Here, we developed a quantitative agent-based modelling framework to test mechanistic hypotheses of chain migration persistence. We defined chain migration and its persistence based on evidence from the highly migratory neural crest model system, where cells within a chain extend and retract filopodia in short-lived cell contacts and move together as a collective. In our agent-based simulations, we began with a set of agents arranged as a chain and systematically probed the influence of model parameters to identify factors critical to the maintenance of the chain migration pattern. We discovered that chain migration persistence requires a high degree of directional bias in both lead and follower cells towards the target. Chain migration persistence was also promoted when lead cells maintained cell contact with followers, but not vice-versa. Finally, providing a path of least resistance in the ECM was not sufficient alone to drive chain persistence. Our results indicate that chain migration persistence depends on the interplay of directional cell movement and biased cell-cell contact.
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