ArticleMolecular biology of the cell2012
Essential roles of zebrafish bmp2a, fgf10, and fgf24 in the specification of the ventral pancreas.
Article in Molecular biology of the cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 26 citations in OpenAlex.
- Fibroblast growth factor receptor signalling dysregulation and targeting in breast cancer.Open biology · 2022Review
- Pharyngeal pouches provide a niche microenvironment for arch artery progenitor specification.Development (Cambridge, England) · 2021Article
- Fibroblast growth factor signaling is required for early somatic gonad development in zebrafish.PLoS genetics · 2017Article
- LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE.Physiological reviews · 2017Review
- Article
- Orchestrating liver development.Development (Cambridge, England) · 2015Review
- The lure of zebrafish in liver research: regulation of hepatic growth in development and regeneration.Current opinion in genetics & development · 2015Review
- FGF signaling is required for anterior but not posterior specification of the murine liver bud.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish.BMC biology · 2013Article
- Translating discovery in zebrafish pancreatic development to human pancreatic cancer: biomarkers, targets, pathogenesis, and therapeutics.Zebrafish · 2013Article
- Pax4 is not essential for beta-cell differentiation in zebrafish embryos but modulates alpha-cell generation by repressing arx gene expression.BMC developmental biology · 2012Article
- Prolonged FGF signaling is necessary for lung and liver induction in Xenopus.BMC developmental biology · 2012Article
- Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration.Developmental biology · 2012Article
- The Fibroblast Growth Factor signaling pathway.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
6 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
In vertebrates, pancreas and liver arise from bipotential progenitors located in the embryonic gut endoderm. Bone morphogenic protein (BMP) and fibroblast growth factor (FGF) signaling pathways have been shown to induce hepatic specification while repressing pancreatic fate. Here we show that BMP and FGF factors also play crucial function, at slightly later stages, in the specification of the ventral pancreas. By analyzing the pancreatic markers pdx1, ptf1a, and hlxb9la in different zebrafish models of BMP loss of function, we demonstrate that the BMP pathway is required between 20 and 24 h postfertilization to specify the ventral pancreatic bud. Knockdown experiments show that bmp2a, expressed in the lateral plate mesoderm at these stages, is essential for ventral pancreas specification. Bmp2a action is not restricted to the pancreatic domain and is also required for the proper expression of hepatic markers. By contrast, through the analysis of fgf10(-/-); fgf24(-/-) embryos, we reveal the specific role of these two FGF ligands in the induction of the ventral pancreas and in the repression of the hepatic fate. These mutants display ventral pancreas agenesis and ectopic masses of hepatocytes. Overall, these data highlight the dynamic role of BMP and FGF in the patterning of the hepatopancreatic region.
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