Trial reportThe Journal of physiology2012
Colloid volume loading does not mitigate decreases in central blood volume during simulated haemorrhage while heat stressed.
Trial report in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Meta-analysis of heat-induced changes in cardiac function from over 400 laboratory-based heat exposure studies.Nature communications · 2025Pooled it
- Tissue oxygen saturation during hyperthermic progressive central hypovolemia.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Trial
- Normothermic central hypovolemia tolerance reflects hyperthermic tolerance.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2014Trial
- Acute volume expansion attenuates hyperthermia-induced reductions in cerebral perfusion during simulated hemorrhage.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Trial
- Sweat loss during heat stress contributes to subsequent reductions in lower-body negative pressure tolerance.Experimental physiology · 2013Trial
- Cardiovascular responses to hot skin at rest and during exercise.Temperature (Austin, Tex.) · 2023Review
- Impact of environmental stressors on tolerance to hemorrhage in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Heat Adaptation in Military Personnel: Mitigating Risk, Maximizing Performance.Frontiers in physiology · 2019Review
- Tolerance to a haemorrhagic challenge during heat stress is improved with inspiratory resistance breathing.Experimental physiology · 2018Article
- Mechanisms of orthostatic intolerance during heat stress.Autonomic neuroscience : basic & clinical · 2016Review
- Human cardiovascular responses to passive heat stress.Comprehensive Physiology · 2015Review
- Beneficial effects of elevating cardiac preload on left-ventricular diastolic function and volume during heat stress: implications toward tolerance during a hemorrhagic insult.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Active and passive heat stress similarly compromise tolerance to a simulated hemorrhagic challenge.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Blood flow distribution during heat stress: cerebral and systemic blood flow.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Heat stress does not augment ventilatory responses to presyncopal limited lower body negative pressure.Experimental physiology · 2013Article
- Elevated local skin temperature impairs cutaneous vasoconstrictor responses to a simulated haemorrhagic challenge while heat stressed.Experimental physiology · 2013Article
- Comparison of cardiovascular response to sinusoidal and constant lower body negative pressure with reference to very mild whole-body heating.Journal of physiological anthropology · 2012Article
- When filling the glass only leaves it half empty! - insight into the cardiovascular physiology of haemorrhage under heat stress.The Journal of physiology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Heat stress results in profound reductions in the capacity to withstand a simulated haemorrhagic challenge; however, this capacity is normalized if the individual is volume loaded prior to the challenge. The present study tested the hypothesis that volume loading during passive heat stress attenuates the reduction in regional blood volumes during a simulated haemorrhagic challenge imposed via lower-body negative pressure (LBNP). Seven subjects underwent 30 mmHg LBNP while normothermic, during passive heat stress (increased internal temperature ∼1◦C), and while continuing to be heated after intravenous colloid volume loading (11 ml kg⁻¹). Relative changes in torso and regional blood volumes were determined by gamma camera imaging with technetium-99m labelled erythrocytes. Heat stress reduced blood volume in all regions (ranging from 7 to 16%), while subsequent volume loading returned those values to normothermic levels. While normothermic,LBNP reduced blood volume in all regions (torso: 22 ± 8%; heart: 18 ± 6%; spleen: 15 ± 8%). During LBNP while heat stressed, the reductions in blood volume in each region were markedly greater when compared to LBNP while normothermic (torso: 73 ± 2%; heart: 72 ± 3%; spleen: 72 ± 5%, all P<0.001 relative to normothermia). Volume loading during heat stress did not alter the extent of the reduction in these blood volumes to LBNP relative to heat stress alone (torso: 73 ± 1%; heart: 72 ± 2%; spleen: 74 ± 3%, all P>0.05 relative to heat stress alone). These data suggest that blood volume loading during passive heat stress (via 11 ml kg⁻¹ of a colloid solution) normalizes regional blood volumes in the torso, but does not mitigate the reduction in central blood volume during a simulated haemorrhagic challenge combined with heat stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.