ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Micro-positron emission tomography imaging of rat brain metabolism during expression of contextual conditioning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Deep brain stimulation for treatment-resistant major depressive disorder: a comparison of two targets and long-term follow-up.Translational psychiatry · 2017Trial
- Bed nucleus of the stria terminalis network responses to unpredictable threat in early alcohol abstinence.Alcohol, clinical & experimental research · 2024Article
- Automated Synthesis of [Pharmaceuticals (Basel, Switzerland) · 2023Article
- Refractory anorexia nervosa in adulthood and nucleus accumbens deep brain stimulation.Surgical neurology international · 2023Article
- A prefrontal-bed nucleus of the stria terminalis circuit limits fear to uncertain threat.eLife · 2020Article
- c-Fos expression following context conditioning and deep brain stimulation in the bed nucleus of the stria terminalis in rats.Scientific reports · 2020Article
- It takes two: Bilateral bed nuclei of the stria terminalis mediate the expression of contextual fear, but not of moderate cued fear.Progress in neuro-psychopharmacology & biological psychiatry · 2020Article
- The lateral neocortex is critical for contextual fear memory reconsolidation.Scientific reports · 2019Article
- Distinct Activity Patterns of the Human Bed Nucleus of the Stria Terminalis and Amygdala during Fear Learning.Neuropsychology review · 2019Review
- Article
- Common neurocircuitry mediating drug and fear relapse in preclinical models.Psychopharmacology · 2019Review
- Electrolytic post-training lesions of the bed nucleus of the stria terminalis block startle potentiation in a cued fear conditioning procedure.Brain structure & function · 2018Article
- Role of the bed nucleus of the stria terminalis in aversive learning and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Review
- Deep brain stimulation in the bed nucleus of the stria terminalis and medial forebrain bundle in a patient with major depressive disorder and anorexia nervosa.Clinical case reports · 2017Article
- Electrical stimulation of the bed nucleus of the stria terminalis reduces anxiety in a rat model.Translational psychiatry · 2017Article
- Dispositional negativity: An integrative psychological and neurobiological perspective.Psychological bulletin · 2016Review
- No effect of glucose administration in a novel contextual fear generalization protocol in rats.Translational psychiatry · 2016Article
- Electrical stimulation in the bed nucleus of the stria terminalis alleviates severe obsessive-compulsive disorder.Molecular psychiatry · 2016Article
- Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.Acta neuropathologica · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using (18)F-fluorodeoxyglucose microPET imaging, we investigated the neurocircuitry of contextual anxiety versus control in awake, conditioned rats (n = 7-10 per group). In addition, we imaged a group expressing cued fear. Simultaneous measurements of startle amplitude and freezing time were used to assess conditioning. To the best of our knowledge, no neuroimaging studies in conditioned rats have been conducted thus far, although visualizing and quantifying the metabolism of the intact brain in behaving animals is clearly of interest. In addition, more insight into the neurocircuitry involved in contextual anxiety may stimulate the development of new treatments for anxiety disorders. Our main finding was hypermetabolism in a cluster comprising the bed nucleus of the stria terminalis (BST) in rats expressing contextual anxiety compared with controls. Analysis of a subset of rats showing the best behavioral results (n = 5 per subgroup) confirmed this finding. We also observed hypermetabolism in the same cluster in rats expressing contextual anxiety compared with rats expressing cued fear. Our results provide novel evidence for a role of the BST in the expression of contextual anxiety.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.