ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Slit1b-Robo3 signaling and N-cadherin regulate apical process retraction in developing retinal ganglion cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- The Slit-Robo signalling pathway in nervous system development: a comparative perspective from vertebrates and invertebrates.Open biology · 2025Review
- Neurogenesis redirects β-catenin from adherens junctions to the nucleus to promote axonal growth.Development (Cambridge, England) · 2023Article
- Signaling - transcription interactions in mouse retinal ganglion cells early axon pathfinding -a literature review.Frontiers in ophthalmology · 2023Review
- LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation.Development (Cambridge, England) · 2022Article
- Extracellular Control of Radial Glia Proliferation and Scaffolding During Cortical Development and Pathology.Frontiers in cell and developmental biology · 2020Review
- Neuronal Delamination and Outer Radial Glia Generation in Neocortical Development.Frontiers in cell and developmental biology · 2020Review
- Effects of neuroactive agents on axonal growth and pathfinding of retinal ganglion cells generated from human stem cells.Scientific reports · 2017Article
- Article
- Molecular codes for cell type specification in Brn3 retinal ganglion cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels.Nature communications · 2016Article
- Characterization of primary cilia during the differentiation of retinal ganglion cells in the zebrafish.Neural development · 2016Article
- Cadherin-2 Is Required Cell Autonomously for Collective Migration of Facial Branchiomotor Neurons.PloS one · 2016Article
- Review
- N-cadherin-based adherens junction regulates the maintenance, proliferation, and differentiation of neural progenitor cells during development.Cell adhesion & migration · 2015Review
- Cadherin-based transsynaptic networks in establishing and modifying neural connectivity.Current topics in developmental biology · 2015Review
- Dynamic gene expression by putative hair-cell progenitors during regeneration in the zebrafish lateral line.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Apical abscission alters cell polarity and dismantles the primary cilium during neurogenesis.Science (New York, N.Y.) · 2014Article
- Connecting the retina to the brain.ASN neuro · 2014Review
- Restricted expression of classic cadherins in the spinal cord of the chicken embryo.Frontiers in neuroanatomy · 2014Article
- Integrative mechanisms of oriented neuronal migration in the developing brain.Annual review of cell and developmental biology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
When neurons exit the cell cycle after their terminal mitosis, they detach from the apical surface of the neuroepithelium. Despite the fact that this detachment is crucial for further neurogenesis and neuronal migration, the underlying mechanisms are still not understood. Here, taking advantage of the genetics and imaging possibilities of the zebrafish retina as a model system, we show by knockdown experiments that the guidance molecule Slit1b and its receptor Robo3 are required for apical retraction of retinal ganglion cells (RGCs). In contrast, N-cadherin seems to be responsible for maintenance of apical attachment, as expression of dominant-negative N-cadherin causes RGCs to lose apical attachments prematurely and rescues retraction in slit1b morphants. These results suggest that Slit-Robo signaling downregulates N-cadherin activity to allow apical retraction in newly generated RGCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.