ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Respiration drives network activity and modulates synaptic and circuit processing of lateral inhibition in the olfactory bulb.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 91 citations in OpenAlex.
- Target-dependent routing of sensory information in the olfactory system.Communications biology · 2026Article
- Theta oscillations are an organizational unit of odor processing in the olfactory bulb.Science advances · 2026Article
- Decoding olfactory bulb output: A behavioral assessment of rate, synchrony, and respiratory phase coding.iScience · 2025Article
- Global coordination of brain activity by the breathing cycle.Nature reviews. Neuroscience · 2025Review
- Ex Vivo Functional Characterization of Mouse Olfactory Bulb Projection Neurons Reveals a Heterogeneous Continuum.eNeuro · 2025Article
- Oscillations in the prefrontal-hippocampal circuit couple to respiration-related oscillations during all phases of a working memory task.Frontiers in behavioral neuroscience · 2025Article
- NMDA receptor antagonist high-frequency oscillations are transmitted via bottom-up feedforward processing.Scientific reports · 2024Article
- Odor encoding by signals in the olfactory bulb.Journal of neurophysiology · 2023Article
- Olfactory modulation of the medial prefrontal cortex circuitry: Implications for social cognition.Seminars in cell & developmental biology · 2022Review
- Breathing coordinates cortico-hippocampal dynamics in mice during offline states.Nature communications · 2022Article
- Smell-induced gamma oscillations in human olfactory cortex are required for accurate perception of odor identity.PLoS biology · 2022Article
- Cell and circuit origins of fast network oscillations in the mammalian main olfactory bulb.eLife · 2021Article
- Generation and Characterization of a Cell Type-Specific, Inducible Cre-Driver Line to Study Olfactory Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Differential Impacts of Repeated Sampling on Odor Representations by Genetically-Defined Mitral and Tufted Cell Subpopulations in the Mouse Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Respiratory regulation & interactions with neuro-cognitive circuitry.Neuroscience and biobehavioral reviews · 2020Review
- Respiration-Locking of Olfactory Receptor and Projection Neurons in the Mouse Olfactory Bulb and Its Modulation by Brain State.Frontiers in cellular neuroscience · 2020Article
- Perspective on the Multiple Pathways to Changing Brain States.Frontiers in systems neuroscience · 2020Review
- Coding of odors in the anterior olfactory nucleus.Physiological reports · 2019Article
- Spatiotemporal dynamics of odor responses in the lateral and dorsal olfactory bulb.PLoS biology · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Respiration produces rhythmic activity in the entire olfactory system, driving neurons in the olfactory epithelium, olfactory bulb (OB), and cortex. The rhythmic nature of this activity is believed to be a critical component of sensory processing. OB projection neurons, mitral and tufted cells exhibit both spiking and subthreshold membrane potential oscillations rhythmically coupled to respiration. However, the network and synaptic mechanisms that produce respiration-coupled activity, and the effects of respiration on lateral inhibition, a major component of sensory processing in OB circuits, are not known. Is respiration-coupled activity in mitral and tufted cells produced by sensory synaptic inputs from nasal airflow alone, cortico-bulbar feedback, or intrinsic membrane properties of the projection neurons? Does respiration facilitate or modulate the activity of inhibitory lateral circuits in the OB? Here, in vivo intracellular recordings from identified mitral and tufted cells in anesthetized rats demonstrate that nasal airflow provides excitatory synaptic inputs to both cell types and drives respiration-coupled spiking. Lateral inhibition, inhibitory postsynaptic potentials evoked by intrabulbar microstimulation, was modulated by respiration. In individual mitral and tufted cells, inhibition was larger at specific respiratory phases. However, lateral inhibition was not uniformly larger during a particular respiratory phase in either cell type. Removing nasal airflow abolished respiration-coupled spiking in both cell types and nearly eliminated spiking in mitral, but not tufted, cells. In the absence of nasal airflow, lateral inhibition was weaker in mitral cells and less modulated in tufted cells. Thus, respiration drives distinct network activities that functionally modulate sensory processing in the OB.
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