ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Comprehensive gene expression profiling in the prefrontal cortex links immune activation and neutrophil infiltration to antinociception.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Trigeminal neuralgia and genetics: A systematic review.Molecular painPooled it
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- Gene expression analysis of Schizophrenia.Bioinformation · 2024Article
- Electroacupuncture Induces Bilateral S1 and ACC Epigenetic Regulation of Genes in a Mouse Model of Neuropathic Pain.Biomedicines · 2023Article
- Potential Neuroimmune Interaction in Chronic Pain: A Review on Immune Cells in Peripheral and Central Sensitization.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Identification of the common differentially expressed genes and pathogenesis between neuropathic pain and aging.Frontiers in neuroscience · 2022Article
- Elevated levels of neutrophil gelatinase-associated lipocalin among OCD patients: an exploratory study.BMC psychiatry · 2021Article
- Lipocalin-2 in Diabetic Complications of the Nervous System: Physiology, Pathology, and Beyond.Frontiers in physiology · 2021Review
- A Transcriptomic Analysis of Neuropathic Pain in Rat Dorsal Root Ganglia Following Peripheral Nerve Injury.Neuromolecular medicine · 2020Article
- Identification of novel differentially expressed genes in retinas of STZ-induced long-term diabetic rats through RNA sequencing.Molecular genetics & genomic medicine · 2020Article
- Role of the Prefrontal Cortex in Pain Processing.Molecular neurobiology · 2019Review
- Metabolism of Docosahexaenoic Acid (DHA) Induces Pyroptosis in BV-2 Microglial Cells.Neuromolecular medicine · 2018Article
- Establishment of a murine pancreatic cancer pain model and microarray analysis of pain‑associated genes in the spinal cord dorsal horn.Molecular medicine reports · 2017Article
- Inflammation, Self-Regulation, and Health: An Immunologic Model of Self-Regulatory Failure.Perspectives on psychological science : a journal of the Association for Psychological Science · 2017Review
- RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment.Neurobiology of disease · 2015Article
- Article
- An epigenetic hypothesis for the genomic memory of pain.Frontiers in cellular neuroscience · 2015Article
- The Effect of Acute and Chronic Social Stress on the Hippocampal Transcriptome in Mice.PloS one · 2015Article
- Social stress increases expression of hemoglobin genes in mouse prefrontal cortex.BMC neuroscience · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional neuroimaging studies have implicated the prefrontal cortex (PFCTX) in descending modulation of pain and the placebo effect. This study was performed to elucidate comprehensive PFCTX gene expression in an animal model of persistent trigeminal pain. Adult male C57BL/6J mice received facial carrageenan injection and showed sustained increase in nociceptive responses. Microarray analyses of differentially expressed genes in the PFCTX at 3 d after injection showed "immune system process" as the dominant ontology term and increased mRNA expression of S100a8, S100a9, Lcn2, Il2rg, Fcgr1, Fcgr2b, C1qb, Ptprc, Ccl12, and Cd52 were verified by RT-PCR. Upregulation of S100A8, S100A9, and lipocalin 2 (LCN2) were confirmed by Western blots, and cells in the PFCTX were double immunolabeled with MPO, indicating they were neutrophils. Analyses of blood of facial carrageenan-injected mice also showed increased mRNA expression of these markers, suggesting transmigration of activated neutrophils into the brain. Other immune-related genes, Il2rg, Fcgr2b, C1qb, Ptprc, and Ccl12 were upregulated in the PFCTX but not blood. Approximately 70% of S100A9-positive cells in the PFCTX of carrageenan-injected mice were located in capillaries adherent to endothelial cells, whereas 30% were within the brain parenchyma. Carrageenan-injected mice showed significantly reduced nociceptive responses after injection of C terminus of murine S100A9 protein in the lateral ventricles and PFCTX but not somatosensory barrel cortex. Together, these findings demonstrate activation of immune-related genes in the PFCTX during inflammatory pain and highlight an exciting role of neutrophils in linking peripheral inflammation with immune activation of the PFCTX and antinociception.
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