ArticleJournal of psychopharmacology (Oxford, England)2012
The selective serotonin reuptake inhibitor, escitalopram, enhances inhibition of prepotent responding and spatial reversal learning.
Article in Journal of psychopharmacology (Oxford, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- The effect of SSRIs on unconditioned anxiety: a systematic review and meta-analysis of animal studies.Psychopharmacology · 2024Pooled it
- Behavioral intervention with task repetition compared to pharmacological intervention with SSRI for enhancement of cognitive control in emotional and non-emotional settings.Psychopharmacology · 2025Trial
- Effects of SSRI treatment on GABA and glutamate levels in an associative relearning paradigm.NeuroImage · 2021Trial
- The Potential Anti Stress-like Properties of Escitalopram on Improvement of Spatial Memory in Rats Subjected to Predictable and Unpredictable Chronic Mild Stress.Advanced biomedical research · 2026Article
- Comparison of Various Dosages of Escitalopram on Anxiety-like Behavior and Body Weight in Male Rats under Severe Chronic Stress.Advanced biomedical research · 2025Article
- Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Fluoxetine degrades luminance perceptual thresholds while enhancing motivation and reward sensitivity.Frontiers in pharmacology · 2023Article
- Increased left dorsolateral prefrontal cortex density following escitalopram intake during relearning: a randomized, placebo-controlled trial in healthy humans.Therapeutic advances in psychopharmacology · 2022Article
- Parallel learning and cognitive flexibility impairments betweenFrontiers in behavioral neuroscience · 2022Article
- Sequential reversal learning: a new touchscreen schedule for assessing cognitive flexibility in mice.Psychopharmacology · 2021Article
- Neurochemistry of Visual Attention.Frontiers in neuroscience · 2021Review
- Glutamatergic and Serotonergic Modulation of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning.Psychology & neuroscience · 2020Article
- Stress vulnerability promotes an alcohol-prone phenotype in a preclinical model of sustained depression.Addiction biology · 2020Article
- Maternal immune activation impairs cognitive flexibility and alters transcription in frontal cortex.Neurobiology of disease · 2019Article
- Dissociable Effects of Tryptophan Supplementation on Negative Feedback Sensitivity and Reversal Learning.Frontiers in behavioral neuroscience · 2019Article
- Prefrontal cortex executive processes affected by stress in health and disease.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- The neural basis of reversal learning: An updated perspective.Neuroscience · 2017Review
- Cognitive flexibility impairment and reduced frontal cortex BDNF expression in the ouabain model of mania.Neuroscience · 2017Article
- 5HTGenes, brain, and behavior · 2017Article
- An Update on the Role of Serotonin and its Interplay with Dopamine for Reward.Frontiers in human neuroscience · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Previous findings indicate treatment with a selective serotonin reuptake inhibitor (SSRI) facilitates behavioral flexibility when conditions require inhibition of a learned response pattern. The present experiment investigated whether acute treatment with the SSRI, escitalopram, affects behavioral flexibility when conditions require inhibition of a naturally biased response pattern (elevated conflict test) and/or reversal of a learned response pattern (spatial reversal learning). An additional experiment was carried out to determine whether escitalopram, at doses that affected behavioral flexibility, also reduced anxiety as tested in the elevated plus-maze. In each experiment, Long-Evans rats received an intraperitoneal injection of either saline or escitalopram (0.03, 0.3 or 1.0 mg/kg) 30 min prior to behavioral testing. Escitalopram, at all doses tested, enhanced acquisition in the elevated conflict test, but did not affect performance in the elevated plus-maze. Escitalopram (0.3 and 1.0 mg/kg) did not alter acquisition of the spatial discrimination, but facilitated reversal learning. In the elevated conflict and spatial reversal learning test, escitalopram enhanced the ability to maintain the relevant strategy after being initially selected. The present findings suggest that enhancing serotonin transmission with an SSRI facilitates inhibitory processes when conditions require a shift away from either a naturally biased response pattern or a learned choice pattern.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.