ArticleThe Journal of biological chemistry2012
Glutathione s-transferase omega 1 activity is sufficient to suppress neurodegeneration in a Drosophila model of Parkinson disease.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed.
- Transcriptomic Analysis of Selenium-Induced Antioxidant Responses in Diploid, Triploid, and Tetraploid Pacific Oysters (Foods (Basel, Switzerland) · 2026Article
- Stress-induced preference for antioxidants byProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Unraveling the functional dynamics of Caenorhabditis elegans stress-responsive omega class GST-44.The FEBS journal · 2025Article
- CoPPIs algorithm: a tool to unravel protein cooperative strategies in pathophysiological conditions.Briefings in bioinformatics · 2025Article
- Glutathione S-Transferase Genes Involved in Response to Short-Term Heat Stress inAntioxidants (Basel, Switzerland) · 2024Article
- Gbb glutathionylation promotes its proteasome-mediated degradation to inhibit synapse growth.The Journal of cell biology · 2023Article
- Loss of STING in parkin mutant flies suppresses muscle defects and mitochondria damage.PLoS genetics · 2023Article
- S-Glutathionylation and S-Nitrosylation in Mitochondria: Focus on Homeostasis and Neurodegenerative Diseases.International journal of molecular sciences · 2022Review
- Tunable Cysteine-Targeting Electrophilic Heteroaromatic Warheads Induce Ferroptosis.Journal of medicinal chemistry · 2022Article
- Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases.Frontiers in molecular biosciences · 2022Review
- Neuroprotective effects ofHeliyon · 2021Article
- Alpha-Synuclein Post-translational Modifications: Implications for Pathogenesis of Lewy Body Disorders.Frontiers in aging neuroscience · 2021Review
- Glutathione S-Transferase Rescues Motor Neuronal Toxicity in Fly Model of Amyotrophic Lateral Sclerosis.Antioxidants (Basel, Switzerland) · 2020Article
- PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress inInternational journal of molecular sciences · 2020Article
- Transcriptome analysis reveals mechanism underlying the differential intestinal functionality of laying hens in the late phase and peak phase of production.BMC genomics · 2019Article
- Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation.Neuron · 2019Article
- An evolving understanding of the S-glutathionylation cycle in pathways of redox regulation.Free radical biology & medicine · 2018Review
- Protein Glutathionylation in the Pathogenesis of Neurodegenerative Diseases.Oxidative medicine and cellular longevity · 2017Review
- Omega Class Glutathione S-Transferase: Antioxidant Enzyme in Pathogenesis of Neurodegenerative Diseases.Oxidative medicine and cellular longevity · 2017Review
- Resveratrol Modulation of Protein Expression inOxidative medicine and cellular longevity · 2017Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A loss-of-function mutation in the gene parkin causes a common neurodegenerative disease that may be caused by mitochondrial dysfunction. Glutathione S-transferase Omega (GSTO) is involved in cell defense mechanisms, but little is known about the role of GSTO in the progression of Parkinson disease. Here, we report that restoration of Drosophila GSTO1 (DmGSTO1), which is down-regulated in parkin mutants, alleviates some of the parkin pathogenic phenotypes and that the loss of DmGSTO1 function enhances parkin mutant phenotypes. We further identified the ATP synthase β subunit as a novel in vivo target of DmGSTO1. We found that glutathionylation of the ATP synthase β subunit is rescued by DmGSTO1 and that the expression of DmGSTO1 partially restores the activity and assembly of the mitochondrial F(1)F(0)-ATP synthase in parkin mutants. Our results suggest a novel mechanism for the protective role of DmGSTO1 in parkin mutants, through the regulation of ATP synthase activity, and provide insight into potential therapies for Parkinson disease neurodegeneration.
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