ArticleThe Journal of biological chemistry2012
Structural basis for sequence-specific DNA recognition by an Arabidopsis WRKY transcription factor.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- WRKY transcription factors in horticultural crops: regulating quality traits and fruit stress responses.Planta · 2026Review
- Unravelling the molecular mechanisms of vegetative-to-reproductive transition in Cynara cardunculus by RNA-Seq analysis.Plant molecular biology · 2026Article
- Structural basis for sequence-specific DNA recognition by a group IId WRKY transcription factor GhWRKY17 in cotton.The Biochemical journal · 2026Article
- Article
- Functional Characterization of OsWRKY7, a Novel WRKY Transcription Factor in Rice.Life (Basel, Switzerland) · 2025Article
- Mechanisms of 10-hydroxyoctadecanoic acid resistance inJournal of bacteriology · 2025Article
- Evidence for vitellogenin DNA-binding in honey bees.Protein science : a publication of the Protein Society · 2025Article
- Unravelling the role of WRKY transcription factors in leaf senescence: Genetic and molecular insights.Journal of advanced research · 2025Review
- Structural basis for the regulation of plant transcription factor WRKY33 by the VQ protein SIB1.Communications biology · 2024Article
- Genomic characterization of WRKY transcription factors related to secoiridoid biosynthesis in Gentiana macrophylla.BMC plant biology · 2024Article
- KaScape: a sequencing-based method for global characterization of protein‒DNA binding affinity.Scientific reports · 2023Article
- Article
- Genome-Wide Identification and Analysis of theGenes · 2023Article
- Rice WRKY13 TF protein binds to motifs in the promoter region to regulate downstream disease resistance-related genes.Functional & integrative genomics · 2023Article
- The Role of Plant Transcription Factors in the Fight against Plant Viruses.International journal of molecular sciences · 2023Review
- Structural basis of DNA binding by the NAC transcription factor ORE1, a master regulator of plant senescence.Plant communications · 2023Article
- Single-cytosine methylation at W-boxes repels binding of WRKY transcription factors through steric hindrance.Plant physiology · 2023Article
- Overexpression of ClWRKY48 from Cunninghamia lanceolata improves Arabidopsis phosphate uptake.Planta · 2023Article
- Article
- Multifaceted roles of WRKY transcription factors in abiotic stress and flavonoid biosynthesis.Frontiers in plant science · 2023Review
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The WRKY family transcription factors regulate plant-specific reactions that are mostly related to biotic and abiotic stresses. They share the WRKY domain, which recognizes a DNA element (TTGAC(C/T)) termed the W-box, in target genes. Here, we determined the solution structure of the C-terminal WRKY domain of Arabidopsis WRKY4 in complex with the W-box DNA by NMR. A four-stranded β-sheet enters the major groove of DNA in an atypical mode termed the β-wedge, where the sheet is nearly perpendicular to the DNA helical axis. Residues in the conserved WRKYGQK motif contact DNA bases mainly through extensive apolar contacts with thymine methyl groups. The importance of these contacts was verified by substituting the relevant T bases with U and by surface plasmon resonance analyses of DNA binding.
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