ArticleInternational urology and nephrology2012
Racial differences in restless legs symptoms and serum ferritin in an incident dialysis patient cohort.
Article in International urology and nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Global prevalence of restless legs syndrome among hemodialysis patients: A systematic review and meta-analysis.Brain and behavior · 2024Pooled it
- Restless legs syndrome among third-trimester pregnant women attending ANC Clinic in public hospitals in North Wollo Zone, Ethiopia.PloS one · 2026Article
- Demographic Differences in Periodic Limb Movement Index and Apnea-Hypopnea Index in a Diverse Clinical Cohort.International journal of environmental research and public health · 2025Article
- Restless legs syndrome in chronic renal failure patients on dialysis.African health sciences · 2023Article
- Nighttime Agitation in Persons with Dementia as a Manifestation of Restless Legs Syndrome.Journal of the American Medical Directors Association · 2021Observational
- Unraveling the Mysteries of Restless Leg Syndrome.Cureus · 2020Review
- Association of restless legs syndrome variants in Korean patients with restless legs syndrome.Sleep · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeRestless legs syndrome (RLS), a debilitating sleep disorder that is frequently reported by CKD patients on dialysis, may be more common in whites than in non-whites. Iron deficiency is associated with RLS, and serum ferritin is higher among African Americans compared to Caucasians in the general population. No prior studies have compared restless legs symptoms and serum ferritin levels of African-American and those of the Caucasian patients on dialysis.
methodsIn a multicenter observational study that included in-person interviews and medical chart review, we studied 210 patients who had recently started renal dialysis. Predictors of restless legs symptoms were examined in a multivariable logistic regression model.
resultsAfrican Americans had a reduced risk of restless legs complaint compared to Caucasian patients (OR, 0.44 [95% CI 0.21-0.93]; P=0.03). African-American patients were also less likely than Caucasian patients to have low serum ferritin values (<100 ng/ml), and among patients with serum ferritin≥100 ng/ml, the average serum ferritin of African-American patients was higher than that of Caucasian patients.
conclusionsFurther study of racial and iron status relationships could advance the understanding of RLS pathophysiology, and RLS is an important patient outcome to monitor, as revised anemia and iron protocols are implemented in the clinical setting.
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Registered trials
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