Evidence map›Paper›PMID 22219083›Full record

ArticleJournal of assisted reproduction and genetics2012

Oocyte cryopreservation in a patient with sickle cell disease prior to hematopoietic stem cell transplantation: first report.

Serena Dovey, Lakshmanan Krishnamurti, Joseph Sanfilippo, Sriya Gunawardena, Patricia Mclendon, Mary Campbell, Sandra Alway, Brenda Efymow, Clarisa Gracia

2 registry-linked trialsOpen access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02225145 completednot on this mapstarted 2014, after this paper: background citation

Fertility Preservation in Females Who Will be Undergoing Gonadotoxic Therapy, Hematopoietic Stem Cell Transplantation, and in Females With Sickle Cell Disease

TypeobservationalSponsorEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Ran2014 to 2017Enrolled22ConditionsHemoglobin, Stem Cell Transplant, Aplastic Anemia
NCT02326597 nacompletednot on this mapstarted 2015, after this paper: background citation

Comparative Effectiveness of a Decision Aid for Therapeutic Options in Sickle Cell Disease

TypeinterventionalSponsorEmory UniversityRan2015 to 2017Enrolled134ConditionsSickle Cell Disease, Sickle Cell Anemia, Hemoglobin SS, Hemoglobin SCArmsDecision Aid Tool, Standard Practice
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Consequences ofFrontiers in endocrinology · 2020
    Article
  10. Oocyte cryopreservation among transmasculine youth: a case series.Journal of assisted reproduction and genetics · 2018
    Article
  11. Indications and Results of HLA-Identical Sibling Hematopoietic Cell Transplantation for Sickle Cell Disease.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Serena DoveyDivision of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh Medical Center/Magee-Womens Hospital, Pittsburgh, PA 15213, USA. doveysl@upmc.edu
Lakshmanan Krishnamurti
Joseph Sanfilippo
Sriya Gunawardena
Patricia Mclendon
Mary Campbell
Sandra Alway
Brenda Efymow
Clarisa Gracia
University of Pittsburgh Medical Center · USMagee-Womens Hospital · USUniversity of Pennsylvania · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report the first occurrence of successful ovarian stimulation, oocyte retrieval and oocyte cryopreservation for fertility preservation in an adolescent with severe sickle cell disease scheduled to undergo a hematopoietic stem cell transplant

methodsCase report.

resultsA 19 year old female with severe sickle cell disease presented for fertility preservation counseling prior to hematopoietic stem cell transplantation. She ultimately underwent ovarian stimulation using a minimal stimulation GnRH antagonist protocol resulting in the successful banking of oocytes prior to transplant. The unique hazards associated with ovarian stimulation in patients with sickle cell disease, such as thrombosis and vaso-occlusive events, are discussed and the methods undertaken to minimize these risks are described.

conclusionsControlled ovarian hyperstimulation and oocyte banking for fertility preservation is feasible in young women with sickle cell disease requiring hematopoietic stem cell transplant and deserves further investigation. Given the elevated risk of thrombosis and predisposition to painful vaso-occlusive events, controlled ovarian hyperstimulation in patients with sickle cell disease is not straightforward and requires a multi-disciplinary team approach to adequately address and minimize the risks in this unique patient population.

Indexed as

CryopreservationFertility PreservationOocytesAdultAnemia, Sickle CellFemaleHematopoietic Stem Cell TransplantationHumansOocyte RetrievalOvulation InductionSeverity of Illness IndexYoung Adult

Identifiers

PMID22219083
PMCPMC3288130
OpenAlexW2079768681

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.