ArticleJournal of molecular evolution2011
Signatures of natural selection in a primate bitter taste receptor.
Article in Journal of molecular evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Cell surface localization of receptors considered nonfunctional and orphan bitter taste receptors.Current research in food science · 2026Article
- Relationships between Bitter Taste Receptor Gene Evolution, Diet, and Gene Repertoire in Primates.Genome biology and evolution · 2024Article
- Differential Activation ofNutrients · 2024Article
- The evolution of bitter taste receptor gene in primates: Gene duplication and selection.Ecology and evolution · 2023Article
- A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution.Molecular biology and evolution · 2021Article
- Positive selection drives the evolution of a primate bitter taste receptor gene.Ecology and evolution · 2021Article
- Bitter taste receptors: Genes, evolution and health.Evolution, medicine, and public health · 2021Review
- Functional divergence of the bitter receptor TAS2R38 in Sulawesi macaques.Ecology and evolution · 2019Article
- Copy Number Variation in TAS2R Bitter Taste Receptor Genes: Structure, Origin, and Population Genetics.Chemical senses · 2016Article
- Article
- Differential bitterness in capsaicin, piperine, and ethanol associates with polymorphisms in multiple bitter taste receptor genes.Physiology & behavior · 2016Article
- Species differences in cannabinoid receptor 2 and receptor responses to cocaine self-administration in mice and rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Adaptive evolution of formyl peptide receptors in mammals.Journal of molecular evolution · 2015Article
- Article
- GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics.Human molecular genetics · 2014Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bitter taste receptors (TAS2Rs) enable animals to detect and avoid toxins in the environment, including noxious defense compounds produced by plants. This suggests that TAS2Rs are under complex pressures from natural selection. To investigate these pressures, we examined signatures of selection in the primate TAS2R38 gene. Whole-gene (1,002 bp) sequences from 40 species representing all major primate taxa uncovered extensive variation. Nucleotide substitutions occurred at 448 positions, resulting in 201 amino acid changes. Two single-nucleotide deletions, one three-nucleotide in-frame deletion, and one premature stop codon were also observed. The rate of non-synonymous substitution (ω = dN/dS), was high in TAS2R38 (ω = 0.60) compared to other genes, but significantly lower than expected under neutrality (P = 4.0 × 10(-9)), indicating that purifying selection has maintained the basic structure of the receptor. However, differences were present among receptor subregions. Non-synonymous rates were significantly lower than expected in transmembrane domains (ω = 0.55, P = 1.18 × 10(-12)) and internal loops (ω = 0.51, P = 7.04 × 10(-5)), but not external loops (ω = 1.16, P = 0.53), and evidence of positive selection was found in external loop 2, which exhibited a high rate (ω = 2.53) consistent with rapid shifts in ligand targeting. These patterns point to a history of rapid yet constrained change in bitter taste responses in the course of primate evolution.
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