Finding the missing links in EGFR.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

19 citing papers in PubMed.

1. Active regulation of the epidermal growth factor receptor by the membrane bilayer.eLife · 2026
   Article
2. Active regulation of the epidermal growth factor receptor by the membrane bilayer.bioRxiv : the preprint server for biology · 2025
   Article
3. Ligand-induced transmembrane conformational coupling in monomeric EGFR.Nature communications · 2022
   Article
4. It Takes More than Two to Tango: Complex, Hierarchal, and Membrane-Modulated Interactions in the Regulation of Receptor Tyrosine Kinases.Cancers · 2022
   Review
5. Plant Leucine-Rich Repeat Receptor Kinase (LRR-RK): Structure, Ligand Perception, and Activation Mechanism.Molecules (Basel, Switzerland) · 2019
   Review
6. More than the sum of the parts: Toward full-length receptor tyrosine kinase structures.IUBMB life · 2019
   Review
7. Lipid-Protein Interplay in Dimerization of Juxtamembrane Domains of Epidermal Growth Factor Receptor.Biophysical journal · 2018
   Article
8. The Dipole Potential Modifies the Clustering and Ligand Binding Affinity of ErbB Proteins and Their Signaling Efficiency.Scientific reports · 2016
   Article
9. Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer.Molecular biology of the cell · 2015
   Article
10. Cell-free expression of functional receptor tyrosine kinases.Scientific reports · 2015
    Article
11. Putting together structures of epidermal growth factor receptors.Current opinion in structural biology · 2014
    Review
12. Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor.Cell reports · 2014
    Article
13. Signal transduction: From the atomic age to the post-genomic era.Cold Spring Harbor perspectives in biology · 2014
    Review
14. Membrane interaction of bound ligands contributes to the negative binding cooperativity of the EGF receptor.PLoS computational biology · 2014
    Article
15. Current Understanding on EGFR and Wnt/β-Catenin Signaling in Glioma and Their Possible Crosstalk.Genes & cancer · 2013
    Review
16. Architecture and membrane interactions of the EGF receptor.Cell · 2013
    Article
17. Structural systems biology and multiscale signaling models.Annals of biomedical engineering · 2012
    Review
18. Bipartite tetracysteine display reveals allosteric control of ligand-specific EGFR activation.ACS chemical biology · 2012
    Article
19. Temporal resolution of autophosphorylation for normal and oncogenic forms of EGFR and differential effects of gefitinib.Biochemistry · 2012
    Article

Corrections and comments

• Comment on
  Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor.2011
• Comment on
  ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding.2011
• Comment on
  Mechanistic insights into the activation of oncogenic forms of EGF receptor.2011

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as