Evidence map›Paper›PMID 22218149›Full record

ArticleRetina (Philadelphia, Pa.)2012

Hyperautofluorescent ring in autoimmune retinopathy.

Luiz H Lima, Jonathan P Greenberg, Vivienne C Greenstein, R Theodore Smith, Juliana M F Sallum, Charles Thirkill, Lawrence A Yannuzzi, Stephen H Tsang

Abstract readCase Reports
In one paragraph

Article in Retina (Philadelphia, Pa.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Unilateral pigmentary retinopathy in an Asian population.Documenta ophthalmologica. Advances in ophthalmology · 2026
    Article
  3. Review
  4. An unusual pAIR: Anti-PKM2 antibody and occult pancreatic adenocarcinoma.American journal of ophthalmology case reports · 2024
    Article
  5. American journal of ophthalmology case reports · 2024
    Article
  6. Article
  7. Review
  8. Management of autoimmune retinopathy treated with intravitreal dexamethasone implant.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Article
  9. Autoimmune Retinopathy, Testing, and Its Controversies.Current ophthalmology reports · 2021
    Article
  10. Article
  11. Retinal Diseases that Can Masquerade as Neurological Causes of Vision Loss.Current neurology and neuroscience reports · 2020
    Review
  12. An update on autoimmune retinopathy.Indian journal of ophthalmology · 2020
    Review
  13. Article
  14. Article
  15. The role of cystoid macular edema as a marker in the progression of non-paraneoplastic autoimmune retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018
    Article
  16. Review
  17. Article
  18. The enigma of autoimmune retinopathy.International ophthalmology clinics · 2015
    Review
  19. Article
  20. Autoimmune retinopathy.American journal of ophthalmology · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Luiz H LimaVitreous, Retina, Macula Consultants of New York and The LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York, USA.
Jonathan P Greenberg
Vivienne C Greenstein
R Theodore Smith
Juliana M F Sallum
Charles Thirkill
Lawrence A Yannuzzi
Stephen H Tsang

Funding

Toward mechanism- and gene-based therapies for retinal degenerationR01EY018213 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stephen H Tsang · 2008 to 2026
$6.6M
NEI NIH HHS R01 EY018213Wellcome Trust
6 · The paper itself

Abstract

purposeTo report the presence of a hyperautofluorescent ring and corresponding spectral-domain optical coherence tomography (SD-OCT) features seen in patients with autoimmune retinopathy.

methodsAll eyes were evaluated by funduscopic examination, full-field electroretinography, fundus autofluorescence, and SD-OCT. Further confirmation of the diagnosis was obtained with immunoblot and immunohistochemistry testing of the patient's serum. Humphrey visual fields and microperimetry were also performed.

resultsFunduscopic examination showed atrophic retinal pigment epithelium (RPE) associated with retinal artery narrowing but without pigment deposits. The scotopic and photopic full-field electroretinograms were nondetectable in three patients and showed a cone-rod pattern of dysfunction in one patient. Fundus autofluorescence revealed a hyperautofluorescent ring in the parafoveal region, and the corresponding SD-OCT demonstrated loss of the photoreceptor inner segment-outer segment junction with thinning of the outer nuclear layer from the region of the hyperautofluorescent ring toward the retinal periphery. The retinal layers were generally intact within the hyperautofluorescent ring, although the inner segment-outer segment junction was disrupted, and the outer nuclear layer and photoreceptor outer segment layer were thinned.

conclusionThis case series revealed the structure of the hyperautofluorescent ring in autoimmune retinopathy using SD-OCT. Fundus autofluorescence and SD-OCT may aid in the diagnosis of autoimmune retinopathy and may serve as a tool to monitor its progression.

Indexed as

Tomography, Optical CoherenceAgedAged, 80 and overAtrophyAutoantibodiesAutoantigensAutoimmune DiseasesFemaleFluorescein AngiographyHumansMaleMiddle AgedParaneoplastic Syndromes, OcularPhotoreceptor Cells, VertebrateRetinaRetinal ArteryAutoantibodiesAutoantigens

Identifiers

PMID22218149
PMCPMC4377132

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.