Evidence map›Paper›PMID 22217949›Full record

Trial reportJournal of clinical psychopharmacology2012

COMT Val158Met, BDNF Val66Met, and OPRM1 Asn40Asp and methamphetamine dependence treatment response: preliminary investigation.

Keith G Heinzerling, James T McCracken, Aimee-Noelle Swanson, Lara A Ray, Steven J Shoptaw

Registry-linked trialAbstract readLetterRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00469508 (A Randomized, Double-Blind, Placebo-Controlled Evaluation of Modafinil vs Placebo for the Treatment of Methamphetamine Dependence), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00469508 phase2completednot on this map

A Randomized, Double-Blind, Placebo-Controlled Evaluation of Modafinil vs Placebo for the Treatment of Methamphetamine Dependence

TypeinterventionalSponsorUniversity of California, Los AngelesRan2007 to 2009Enrolled71ConditionsMethamphetamine DependenceArmsModafinil, Placebo
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Keith G Heinzerling
James T McCracken
Aimee-Noelle Swanson
Lara A Ray
Steven J Shoptaw

Funding

UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAPHAEL J LANDOVITZ · 1997 to 2026
$53.5M
UCLA Medication Development Unit for Stimulant AbuseP50DA018185 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHOPTAW, STEVEN J · 2004 to 2009
$5.8M
Pharmacogenomics and Medication Development for Methamphetamine DependenceK23DA023558 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HEINZERLING, KEITH GREGORY · 2008 to 2012
$848k
NIDA NIH HHS 1 K23 DA 023558NIDA NIH HHS 1 P50 DA 18185NIDA NIH HHS K23 DA023558NIDA NIH HHS P50 DA018185NIMH NIH HHS P30 MH058107
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AllelesCentral Nervous System StimulantsMethamphetamineAdultAmphetamine-Related DisordersBehavior TherapyBrain-Derived Neurotrophic FactorCatechol O-MethyltransferaseCognitive Behavioral TherapyFemaleGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideReceptors, Opioid, muBrain-Derived Neurotrophic FactorCatechol O-MethyltransferaseCentral Nervous System StimulantsMethamphetamineOPRM1 protein, humanReceptors, Opioid, mu

Identifiers

PMID22217949
PMCPMC3597465

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.