ReviewThe Journal of investigative dermatology2012
Skin barrier disruption: a requirement for allergen sensitization?
Review in The Journal of investigative dermatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed.
- A prospective study of the safety and efficacy of a combined bipolar radiofrequency, intense pulsed light, and infrared diode laser treatment for global facial photoaging.Lasers in medical science · 2017Trial
- Intradermal grass pollen immunotherapy increases TThe Journal of allergy and clinical immunology · 2017Trial
- Microbiome-Derived Metabolic Signaling in the Gut-Skin Axis: Implications for Nutricosmetics and Healthy Skin Aging.Nutrients · 2026Review
- Skin Barrier Dysfunction in Contact and Atopic Dermatitis: A Comparative Review.Allergy, asthma & immunology research · 2026Review
- Exploring the Therapeutic Potential of Crisaborole Gel in Atopic Dermatitis: A Review.Recent advances in drug delivery and formulation · 2026Review
- Targeted therapies in atopic dermatitis: toward endotype-driven precision medicine and disease modification.Frontiers in immunology · 2026Review
- Novel drug delivery systems in topical treatment of atopic dermatitis.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- High Transepidermal Water Loss at the Site of Wound Closure Is Associated With Increased Recurrence of Diabetic Foot Ulcers: The NIDDK Diabetic Foot Consortium TEWL Study.Diabetes care · 2025Article
- Updates in Metal Allergy: A Review of New Pathways of Sensitization, Exposure, and Treatment.Current allergy and asthma reports · 2025Review
- Clinical Characteristics and Patch Test Results in 57 Patients with Contact Dermatitis in Southern Taiwan.Journal of clinical medicine · 2025Article
- Enhancing Transcutaneous Drug Delivery: Advanced Perspectives on Skin Models.JID innovations : skin science from molecules to population health · 2025Review
- Beyond the dichotomy: understanding the overlap between atopic dermatitis and psoriasis.Frontiers in immunology · 2025Review
- IL-4, IL-13, TNF-α and IFN-γ Downregulate CLDN8 Expression Through Activating JAK Signaling Pathway in HaCaT Cells.Clinical, cosmetic and investigational dermatology · 2025Article
- Oral administration ofFrontiers in microbiology · 2025Article
- Glucose binds and activates NSUN2 to promote translation and epidermal differentiation.Nucleic acids research · 2024Article
- Deficient functional wound closure as measured by elevated trans-epidermal water loss predicts chronic wound recurrence: An exploratory observational study.Scientific reports · 2024Observational
- Basophils Play a Protective Role in the Recovery of Skin Barrier Function from Mechanical Injury in Mice.The Journal of investigative dermatology · 2024Article
- [Inflammatory dermatoses in children and adolescents : Diagnosis and treatment of atopic dermatitis and psoriasis].Dermatologie (Heidelberg, Germany) · 2024Review
- Efficacy of Topical Application of a Skin Moisturizer Containing Pseudo-Ceramide and a Eucalyptus Leaf Extract on Atopic Dermatitis: A Review.Journal of clinical medicine · 2024Review
- Development of a mini pig model of peanut allergy.Frontiers in allergy · 2024Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
For at least half a century, noninvasive techniques have been available to quantify skin barrier function, and these have shown that a number of human skin conditions and disorders are associated with defects in skin permeability. In the past decade, several genes responsible for skin barrier defects observed in both monogenetic and complex polygenic disorders have been elucidated and functionally characterized. This has led to an explosion of work in the past 6 years that has identified pathways connecting epidermal barrier disruption and antigen uptake, as well as the quality and/or magnitude of the antigen-specific adaptive immune response. This review will introduce the notion that diseases arise from the dynamic crosstalk that occurs between skin barrier and the immune system using atopic dermatitis or eczema as the disease prototype. Nevertheless, the concepts put forth are highly relevant to a number of antigen-driven disorders for which skin barrier is at least transiently compromised, such as psoriasis, allergic contact dermatitis, and blistering disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.