ReviewProceedings. Biological sciences2012
The role of robustness in phenotypic adaptation and innovation.
Review in Proceedings. Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Emergence Biases in Molecular Evolution.Genome biology and evolution · 2026Review
- Internalized Evolutionary Inertia on Body Plan Evolution.Evolution & development · 2026Review
- A complex network perspective on brain disease.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Mutagenic impact of picric acid on chloroplast genome and a selection of biological attributes of Brassica napus L. (Brassicaceae).BMC genomics · 2025Article
- Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network.Nature communications · 2025Article
- Article
- Evolutionary Implications of Self-Assembling Cybernetic Materials with Collective Problem-Solving Intelligence at Multiple Scales.Entropy (Basel, Switzerland) · 2024Article
- Mutational robustness and the role of buffer genes in evolvability.The EMBO journal · 2024Review
- Viral Receptor-Binding Protein Evolves New Function through Mutations That Cause Trimer Instability and Functional Heterogeneity.Molecular biology and evolution · 2024Article
- Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network.bioRxiv : the preprint server for biology · 2024Article
- The effect of mutational robustness on the evolvability of multicellular organisms and eukaryotic cells.Journal of evolutionary biology · 2023Article
- Robustness and innovation in synthetic genotype networks.Nature communications · 2023Article
- Spontaneous, Artificial, and Genome Editing-Mediated Mutations inInternational journal of molecular sciences · 2022Review
- Selection in a growing colony biases results of mutation accumulation experiments.Scientific reports · 2022Article
- Evolutionary Pathways and Trajectories in Antibiotic Resistance.Clinical microbiology reviews · 2021Article
- Bivalent chromatin as a therapeutic target in cancer: An in silico predictive approach for combining epigenetic drugs.PLoS computational biology · 2021Article
- In vitro selected GUAA tetraloop-binding receptors with structural plasticity and evolvability towards natural RNA structural modules.Nucleic acids research · 2021Article
- A model of developmental canalization, applied to human cranial form.PLoS computational biology · 2021Article
- Evolutionary Variation in MADS Box Dimerization Affects Floral Development and Protein Abundance in Maize.The Plant cell · 2020Article
- Article
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1 author.
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Abstract
Phenotypes that vary in response to DNA mutations are essential for evolutionary adaptation and innovation. Therefore, it seems that robustness, a lack of phenotypic variability, must hinder adaptation. The main purpose of this review is to show why this is not necessarily correct. There are two reasons. The first is that robustness causes the existence of genotype networks--large connected sets of genotypes with the same phenotype. I discuss why genotype networks facilitate phenotypic variability. The second reason emerges from the evolutionary dynamics of evolving populations on genotype networks. I discuss how these dynamics can render highly robust phenotypes more variable, using examples from protein and RNA macromolecules. In addition, robustness can help avoid an important evolutionary conflict between the interests of individuals and populations-a conflict that can impede evolutionary adaptation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.