ArticlePLoS neglected tropical diseases2011
Individuals with Le(a+b-) blood group have increased susceptibility to symptomatic vibrio cholerae O1 infection.
Article in PLoS neglected tropical diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Individual and Household Risk Factors for Symptomatic Cholera Infection: A Systematic Review and Meta-analysis.The Journal of infectious diseases · 2018Pooled it
- Anti-O-specific polysaccharide (OSP) immune responses following vaccination with oral cholera vaccine CVD 103-HgR correlate with protection against cholera after infection with wild-type Vibrio cholerae O1 El Tor Inaba in North American volunteers.PLoS neglected tropical diseases · 2018Trial
- Investigating ABO Blood Groups and Secretor Status in Relation to SARS-CoV-2 Infection and COVID-19 Severity.Journal of personalized medicine · 2024Review
- Assessment of the influence of ABO blood groups on oral cholera vaccine immunogenicity in a cholera endemic area in Zambia.BMC public health · 2023Article
- Association of Secretor Status with Enteropathy and Growth among Children in Bangladesh Aged 1-24 Months.The American journal of tropical medicine and hygiene · 2022Article
- Contrasting Epidemiology of Cholera in Bangladesh and Africa.The Journal of infectious diseases · 2021Review
- "Mysterious veil" between the blood group system and pathogens.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021Article
- Gold Standard Cholera Diagnostics Are Tarnished by Lytic Bacteriophage and Antibiotics.Journal of clinical microbiology · 2020Article
- Human Neonatal Rotavirus Vaccine (RV3-BB) Produces Vaccine Take Irrespective of Histo-Blood Group Antigen Status.The Journal of infectious diseases · 2020Article
- Human Milk Oligosaccharides: Health Benefits, Potential Applications in Infant Formulas, and Pharmacology.Nutrients · 2020Review
- Immune responses to O-specific polysaccharide (OSP) in North American adults infected with Vibrio cholerae O1 Inaba.PLoS neglected tropical diseases · 2019Article
- Crystal structures of cholera toxin in complex with fucosylated receptors point to importance of secondary binding site.Scientific reports · 2019Article
- Position of human blood group O(H) and phenotype-determining enzymes in growth and infectious disease.Annals of the New York Academy of Sciences · 2018Review
- Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii.ACS infectious diseases · 2018Article
- Blood type biochemistry and human disease.Wiley interdisciplinary reviews. Systems biology and medicine · 2016Review
- Histo-blood group glycans in the context of personalized medicine.Biochimica et biophysica acta · 2016Review
- Blood group A and D negativity are associated with symptomatic West Nile virus infection.Transfusion · 2016Article
- High-Resolution Crystal Structures Elucidate the Molecular Basis of Cholera Blood Group Dependence.PLoS pathogens · 2016Article
- Blood Groups in Infection and Host Susceptibility.Clinical microbiology reviews · 2015Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundHuman genetic factors such as blood group antigens may affect the severity of infectious diseases. Presence of specific ABO and Lewis blood group antigens has been shown previously to be associated with the risk of different enteric infections. The aim of this study was to determine the relationship of the Lewis blood group antigens with susceptibility to cholera, as well as severity of disease and immune responses to infection. METHODOLOGY: We determined Lewis and ABO blood groups of a cohort of patients infected by Vibrio cholerae O1, their household contacts, and healthy controls, and analyzed the risk of symptomatic infection, severity of disease if infected and immune response following infection. PRINCIPAL
findingsWe found that more individuals with cholera expressed the Le(a+b-) phenotype than the asymptomatic household contacts (OR 1.91, 95% CI 1.03-3.56) or healthy controls (OR 1.90, 95% CI 1.13-3.21), as has been seen previously for the risk of symptomatic ETEC infection. Le(a-b+) individuals were less susceptible to cholera and if infected, required less intravenous fluid replacement in hospital, suggesting that this blood group may be associated with protection against V. cholerae O1. Individuals with Le(a-b-) blood group phenotype who had symptomatic cholera had a longer duration of diarrhea and required higher volumes of intravenous fluid replacement. In addition, individuals with Le(a-b-) phenotype also had lessened plasma IgA responses to V. cholerae O1 lipopolysaccharide on day 7 after infection compared to individuals in the other two Lewis blood group phenotypes.
conclusionIndividuals with Lewis blood type Le(a+b-) are more susceptible and Le(a-b+) are less susceptible to V. cholerae O1 associated symptomatic disease. Presence of this histo-blood group antigen may be included in evaluating the risk for cholera in a population, as well as in vaccine efficacy studies, as is currently being done for the ABO blood group antigens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.