ArticlePloS one2011
Novel cytochrome P450, cyp6a17, is required for temperature preference behavior in Drosophila.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Leaving against medical assumptions: reframing "AMA" discharges in the care of people who use drugs.CJEM · 2026Article
- Cold-Sensing TRP Channels and Temperature Preference Modulate Ovarian Development in the Model OrganismInternational journal of molecular sciences · 2025Article
- Genome-Wide Profiling of P450 Gene Expression Reveals Caste-Specific and Developmental Patterns inInternational journal of molecular sciences · 2025Article
- Genomes of the cosmopolitan fruit pest Bactrocera dorsalis (Diptera: Tephritidae) reveal its global invasion history and thermal adaptation.Journal of advanced research · 2023Article
- Gene Expression Analysis Reveals Potential Regulatory Factors Response to Temperature Stress inGenes · 2023Article
- Chemokine production induced by Corynebacterium pseudotuberculosis in a murine model.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila.Nature communications · 2022Article
- The Role of Cytochrome P450 4C1 and Carbonic Anhydrase 3 in Response to Temperature Stress inInsects · 2021Article
- Parallel and population-specific gene regulatory evolution in cold-adapted fly populations.Genetics · 2021Article
- Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila.Scientific reports · 2020Article
- Cytochrome P450 metabolism mediates low-temperature resistance in pinewood nematode.FEBS open bio · 2020Article
- Hidden genetic variation shapes the structure of functional elements in Drosophila.Nature genetics · 2018Article
- Parallel Evolution of Copy-Number Variation across Continents in Drosophila melanogaster.Molecular biology and evolution · 2016Article
- Functional genomics of acclimation and adaptation in response to thermal stress in Daphnia.BMC genomics · 2014Article
- The molecular evolution of cytochrome P450 genes within and between drosophila species.Genome biology and evolution · 2014Article
- The mechanisms underlying α-amanitin resistance in Drosophila melanogaster: a microarray analysis.PloS one · 2014Article
- Detecting highly differentiated copy-number variants from pooled population sequencing.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2013Article
- Discriminating fever behavior in house flies.PloS one · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Perception of temperature is an important brain function for organisms to survive. Evidence suggests that temperature preference behavior (TPB) in Drosophila melanogaster, one of poikilothermal animals, is regulated by cAMP-dependent protein kinase (PKA) signaling in mushroom bodies of the brain. However, downstream targets for the PKA signaling in this behavior have not been identified. From a genome-wide search for the genes regulated by PKA activity in the mushroom bodies, we identified the cyp6a17 Cytochrome P450 gene as a new target for PKA. Our detailed analysis of mutants by genetic, molecular and behavioral assays shows that cyp6a17 is essential for temperature preference behavior. cyp6a17 expression is enriched in the mushroom bodies of the adult brain. Tissue-specific knockdown and rescue experiments demonstrate that cyp6a17 is required in the mushroom bodies for normal temperature preference behavior. This is the first study, to our knowledge, to show PKA-dependent expression of a cytochrome P450 gene in the mushroom bodies and its role as a key factor for temperature preference behavior. Taken together, this study reveals a new PKA-Cytochrome P450 pathway that regulates the temperature preference behavior.
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