ArticlePloS one2011
The prognostic significance of apoptosis-related biological markers in Chinese gastric cancer patients.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bcl-2 expression and patient survival in gastric cancer: a systematic review of the literature with meta-analysis.Medical oncology (Northwood, London, England) · 2015Pooled it
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- Effect of perioperative blood transfusion on prognosis of patients with gastric cancer: a retrospective analysis of a single center database.BMC cancer · 2018Article
- Gastric Cancer Cell Lines Have DifferentCanadian journal of gastroenterology & hepatology · 2018Article
- Regulation of apoptosis is impaired in atrophic gastritis associated with gastric cancer.BMC gastroenterology · 2017Article
- Follow-up after curative resection for gastric cancer: Is it time to tailor it?World journal of gastroenterology · 2017Article
- Prognostic significance of cancer family history for patients with gastric cancer: a single center experience from China.Oncotarget · 2016Article
- Association Between Amplification and Expression of C-MYC Gene and Clinicopathological Characteristics of Stomach Cancer.Iranian Red Crescent medical journal · 2016Article
- Biomarkers for gastric cancer: Progression in early diagnosis and prognosis (Review).Oncology letters · 2015Article
- Detecting of gastric cancer by Bcl-2 and Ki67.International journal of clinical and experimental pathology · 2015Article
- Study of C-MYC amplification and expression in Iranian gastric cancer samples using CISH and IHC methods.Advanced biomedical research · 2015Article
- How prognostic and predictive biomarkers are transforming our understanding and management of advanced gastric cancer.The oncologist · 2014Review
- The expression and clinical significance of miR-132 in gastric cancer patients.Diagnostic pathology · 2014Article
- Prediction of tumor recurrence after curative resection in gastric carcinoma based on bcl-2 expression.World journal of surgical oncology · 2014Article
- XB130 promotes proliferation and invasion of gastric cancer cells.Journal of translational medicine · 2014Article
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6 authors.
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Abstract
BACKGROUND AND
objectiveThe prognosis varied among the patients with the same stage, therefore there was a need for new prognostic and predictive factors. The aim of this study was to evaluate the relationship of apoptosis-related biological markers such as p53, bcl-2, bax, and c-myc, and clinicopathological features and their prognostic value.
methodsFrom 1996 to 2007, 4426 patients had undergone curative D2 gastrectomy for gastric cancer at Fudan University Shanghai Cancer Center. Among 501 patients, the expression levels of p53, bcl-2, bax, and c-myc were examined by immunohistochemistry. The prognostic value of biological markers and the correlation between biological markers and other clinicopathological factors were investigated.
resultsThere were 339 males and 162 females with a mean age of 57. The percentages of positive expression of p53, bcl-2, bax, and c-myc were 65%, 22%, 43%, and 58%, respectively. There was a strong correlation between p53, bax, and c-myc expression (P=0.00). There was significant association between bcl-2, and bax expression (P<0.05). p53 expression correlated with histological grade (P=0.01); bcl-2 expression with pathological stage (P=0.00); bax expression with male (P=0.02), histological grade (P=0.01), Borrmann type (P=0.01), tumor location (P=0.00), lymph node metastasis (P=0.03), and pathological stage (P=0.03); c-myc expression with Borrmann type (P=0.00). bcl-2 expression was related with good survival in univariate analysis (P=0.01). Multivariate analysis showed that bcl-2 expression and pathological stage were defined as independent prognostic factors. There were significant differences of overall 5-year survival rates according to bcl-2 expression or not in stage IIB (P=0.03).
conclusionThe expression of bcl-2 was an independent prognostic factor for patients with gastric cancer; it might be a candidate for the gastric cancer staging system.
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