ArticlePloS one2011
Fetal microchimeric cells in blood of women with an autoimmune thyroid disease.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- [The role of microchimerism in the development of endocrine diseases (using autoimmune thyroid diseases and type 1 diabetes mellitus as examples)].Problemy endokrinologii · 2026Review
- Thyroid dysfunction in ageing populations.Endocrine connections · 2025Review
- Differences in autoimmune thyroid diseases between females and males: the result of a complex interconnection of factors.Endocrine · 2025Review
- The when, what, and where of naturally-acquired microchimerism.Seminars in immunopathology · 2025Review
- Reinterpreting patterns of variation in human thyroid function: An evolutionary ecology perspective.Evolution, medicine, and public health · 2021Review
- Low prevalence of symptomatic thyroid diseases and thyroid cancers in HIV-infected patients.Scientific reports · 2019Article
- Thyroid and celiac disease in pediatric age: a literature review.Acta bio-medica : Atenei Parmensis · 2018Review
- Variables Contributing to Thyroid (Dys)Function in Pregnant Women: More than Thyroid Antibodies?European thyroid journal · 2018Article
- Autoimmune Thyroiditis and Myasthenia Gravis.Frontiers in endocrinology · 2017Review
- Statistical Methods for Unusual Count Data: Examples From Studies of Microchimerism.American journal of epidemiology · 2016Article
- Fetal microchimerism and maternal health: a review and evolutionary analysis of cooperation and conflict beyond the womb.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Review
- Naturally acquired microchimerism: implications for transplantation outcome and novel methodologies for detection.Chimerism · 2014Review
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- Article
- The immunopathogenesis of chronic autoimmune thyroiditis one century after hashimoto.European thyroid journal · 2013Review
- Mother and child T cell receptor repertoires: deep profiling study.Frontiers in immunology · 2013Article
- Article
- Review
- Fetal microchimeric cells in blood and thyroid glands of women with an autoimmune thyroid disease.ChimerismArticle
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextHashimoto's thyroiditis (HT) and Graves' disease (GD), two autoimmune thyroid diseases (AITD), occur more frequently in women than in men and show an increased incidence in the years following parturition. Persisting fetal cells could play a role in the development of these diseases.
objectiveAim of this study was to detect and characterize fetal cells in blood of postpartum women with and without an AITD.
participantsEleven patients with an AITD and ten healthy volunteers, all given birth to a son maximum 5 years before analysis, and three women who never had been pregnant, were included. None of them had any other disease of the thyroid which could interfere with the results obtained.
methodsFluorescence in situ hybridization (FISH) and repeated FISH were used to count the number of male fetal cells. Furthermore, the fetal cells were further characterized.
resultsIn patients with HT, 7 to 11 fetal cells per 1.000.000 maternal cells were detected, compared to 14 to 29 fetal cells in patients with GD (p=0.0061). In patients with HT, mainly fetal CD8(+) T cells were found, while in patients with GD, fetal B and CD4(+) T cells were detected. In healthy volunteers with son, 0 to 5 fetal cells were observed, which was significantly less than the number observed in patients (p<0,05). In women who never had been pregnant, no male cells were detected.
conclusionThis study shows a clear association between fetal microchimeric cells and autoimmune thyroid diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.