ArticlePloS one2011
Circular DNA intermediate in the duplication of Nile tilapia vasa genes.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- SVA Retrotransposons and a Low Copy Repeat in Humans and Great Apes: A Mobile Connection.Molecular biology and evolution · 2022Article
- Circular DNA intermediates in the generation of large human segmental duplications.BMC genomics · 2020Article
- QTL Fine Mapping for Sex Determination Region in Bighead Carp (Hypophthalmichthys nobilis) and Comparison with Silver Carp (Hypophthalmichthys molitrix).Marine biotechnology (New York, N.Y.) · 2020Article
- Article
- A high quality assembly of the Nile Tilapia (Oreochromis niloticus) genome reveals the structure of two sex determination regions.BMC genomics · 2017Article
- Review
- A sex-associated sequence identified by RAPD screening in gynogenetic individuals of turbot (Scophthalmus maximus).Molecular biology reports · 2014Article
- Gene duplication in an African cichlid adaptive radiation.BMC genomics · 2014Article
- Sexually dimorphic expression of vasa isoforms in the tongue sole (Cynoglossus semilaevis).PloS one · 2014Article
- Sorting genomes with rearrangements and segmental duplications through trajectory graphs.BMC bioinformatics · 2013Article
- Mechanisms of Gene Duplication and Translocation and Progress towards Understanding Their Relative Contributions to Animal Genome Evolution.International journal of evolutionary biology · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
vasa is a highly conserved RNA helicase involved in animal germ cell development. Among vertebrate species, it is typically present as a single copy per genome. Here we report the isolation and sequencing of BAC clones for Nile tilapia vasa genes. Contrary to a previous report that Nile tilapia have a single copy of the vasa gene, we find evidence for at least three vasa gene loci. The vasa gene locus was duplicated from the original site and integrated into two distant novel sites. For one of these insertions we find evidence that the duplication was mediated by a circular DNA intermediate. This mechanism of gene duplication may explain the origin of isolated gene duplicates during the evolution of fish genomes. These data provide a foundation for studying the role of multiple vasa genes in the development of tilapia gonads, and will contribute to investigations of the molecular mechanisms of sex determination and evolution in cichlid fishes.
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Registered trials
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