ArticlePloS one2011
Adult body weight is programmed by a redox-regulated and energy-dependent process during the pronuclear stage in mouse.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 64 citations in OpenAlex.
- How Early-Life Programming During Embryogenesis Imprints Cellular Memory.International journal of molecular sciences · 2025Review
- Calcium signals shape metabolic control of H3K27ac and H3K18la to regulate EGA.bioRxiv : the preprint server for biology · 2025Article
- PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth†.Biology of reproduction · 2022Article
- The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspring.Human reproduction (Oxford, England) · 2020Article
- Transient Changes of Metabolism at the Pronuclear Stage in Mice Influences Skeletal Muscle Phenotype in Adulthood.International journal of molecular sciences · 2020Article
- Modulators of calcium signalling at fertilization.Open biology · 2020Review
- Increased blood pressure and impaired endothelial function after accelerated growth in IVF/ICSI children.Human reproduction open · 2020Article
- Article
- TRPM7 and CaProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Insulin and branched-chain amino acid depletion during mouse preimplantation embryo culture programmes body weight gain and raised blood pressure during early postnatal life.Biochimica et biophysica acta. Molecular basis of disease · 2018Article
- Factors and molecules that could impact cell differentiation in the embryo generated by nuclear transfer.Organogenesis · 2017Review
- Microfluidic analysis of oocyte and embryo biomechanical properties to improve outcomes in assisted reproductive technologies.Molecular human reproduction · 2017Review
- Signal transduction in mammalian oocytes during fertilization.Cell and tissue research · 2016Review
- Sex and the preimplantation embryo: implications of sexual dimorphism in the preimplantation period for maternal programming of embryonic development.Cell and tissue research · 2016Review
- Endoplasmic reticulum stress signaling in mammalian oocytes and embryos: life in balance.International review of cell and molecular biology · 2015Review
- Sexually dimorphic effect of in vitro fertilization (IVF) on adult mouse fat and liver metabolomes.Endocrinology · 2014Article
- Effect of holding equine oocytes in meiosis inhibitor-free medium before in vitro maturation and of holding temperature on meiotic suppression and mitochondrial energy/redox potential.Reproductive biology and endocrinology : RB&E · 2014Article
- Use of a mouse in vitro fertilization model to understand the developmental origins of health and disease hypothesis.Endocrinology · 2014Article
- Advances in quality control: mouse embryo morphokinetics are sensitive markers of in vitro stress.Human reproduction (Oxford, England) · 2013Article
- Systems genetics implicates cytoskeletal genes in oocyte control of cloned embryo quality.Genetics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
In mammals fertilization triggers a series of Ca(2+) oscillations that not only are essential for events of egg activation but also stimulate oxidative phosphorylation. Little is known, however, about the relationship between quantitative changes in egg metabolism and specific long-term effects in offspring. This study assessed whether post-natal growth is modulated by early transient changes in NAD(P)H and FAD(2+) in zygotes. We report that experimentally manipulating the redox potential of fertilized eggs during the pronuclear (PN) stage affects post-natal body weight. Exogenous pyruvate induces NAD(P)H oxidation and stimulates mitochondrial activity with resulting offspring that are persistently and significantly smaller than controls. Exogenous lactate stimulates NAD(+) reduction and impairs mitochondrial activity, and produces offspring that are smaller than controls at weaning but catch up after weaning. Cytosolic alkalization increases NAD(P)(+) reduction and offspring of normal birth-weight become significantly and persistently larger than controls. These results constitute the first report that post-natal growth rate is ultimately linked to modulation of NAD(P)H and FAD(2+) concentration as early as the PN stage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.