ArticlePloS one2011
Risk factors for pre-treatment mortality among HIV-infected children in rural Zambia: a cohort study.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Mortality and its predictors among human immunodeficiency virus-infected children younger than 15 years receiving antiretroviral therapy in Ethiopia: a systematic review and meta-analysis.BMC infectious diseases · 2024Pooled it
- Implementation of antiretroviral therapy guidelines for under-five children in Tanzania: translating recommendations into practice.Journal of the International AIDS Society · 2015Guideline
- Trial
- Use of machine learning in predicting continuity of HIV treatment in selected Nigerian States.PLOS global public health · 2025Article
- Article
- Micronutrients and nutritional status among children living with HIV with and without severe acute malnutrition: IMPAACT P1092.BMC nutrition · 2023Article
- Survival time and predictors of death among HIV infected under five children after initiation of anti -retroviral therapy in West Amhara Referral Hospitals, Northwest Ethiopia.BMC pediatrics · 2022Article
- Survival status and predictors of mortality among HIV-positive children initiated antiretroviral therapy in Bahir Dar town public health facilities Amhara region, Ethiopia, 2020.SAGE open medicine · 2022Article
- Risk factors for postdischarge mortality following hospitalization for severe acute malnutrition in Zimbabwe and Zambia.The American journal of clinical nutrition · 2021Article
- Mortality rate among HIV-positive children on ART in Northwest Ethiopia: a historical cohort study.BMC public health · 2020Article
- Patterns of Growth, Body Composition, and Lipid Profiles in a South African Cohort of Human Immunodeficiency Virus-Infected and Uninfected Children: A Cross-Sectional Study.Journal of the Pediatric Infectious Diseases Society · 2018Article
- Effects of undernutrition on survival of human immunodeficiency virus positive children on antiretroviral therapy.Italian journal of pediatrics · 2018Article
- Mortality in a Cohort of HIV-Infected Children: A 12-Month Outcome of Antiretroviral Therapy in Makurdi, Nigeria.Advances in medicine · 2018Article
- Clinical associations of white matter damage in cART-treated HIV-positive children in South Africa.Journal of neurovirology · 2015Article
- Mortality and Loss to Follow up Before Initiation of Antiretroviral Therapy Among HIV-Infected Children Eligible for HIV Treatment.Infectious disease reports · 2014Article
- Predictors of Mortality in a Clinic Cohort of HIV-1 Infected Children Initiated on Antiretroviral Therapy in Jos, Nigeria.Journal of AIDS & clinical research · 2014Article
- Article
- Immediate antiretroviral therapy in young HIV-infected children: benefits and risks.Current opinion in HIV and AIDS · 2014Review
- Incidence and predictors of severe anemia in Asian HIV-infected children using first-line antiretroviral therapy.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2013Article
- Paediatric HIV care in sub-Saharan Africa: clinical presentation and 2-year outcomes stratified by age group.Tropical medicine & international health : TM & IH · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMany HIV-infected children in sub-Saharan Africa enter care at a late stage of disease. As preparation of the child and family for antiretroviral therapy (ART) can take several clinic visits, some children die prior to ART initiation. This study was undertaken to determine mortality rates and clinical predictors of mortality during the period prior to ART initiation.
methodsA prospective cohort study of HIV-infected treatment-naïve children was conducted between September 2007 and September 2010 at the HIV clinic at Macha Hospital in rural Southern Province, Zambia. HIV-infected children younger than 16 years of age who were treatment-naïve at study enrollment were eligible for analysis. Mortality rates prior to ART initiation were calculated and risk factors for mortality were evaluated.
results351 children were included in the study, of whom 210 (59.8%) were eligible for ART at study enrollment. Among children ineligible for ART at enrollment, 6 children died (mortality rate: 0.33; 95% CI:0.15, 0.74). Among children eligible at enrollment, 21 children died before initiation of ART and their mortality rate (2.73 per 100 person-years; 95% CI:1.78, 4.18) was significantly higher than among children ineligible for ART (incidence rate ratio: 8.20; 95% CI:3.20, 24.83). In both groups, mortality was highest in the first three months of follow-up. Factors associated with mortality included younger age, anemia and lower weight-for-age z-score at study enrollment.
conclusionsThese results underscore the need to increase efforts to identify HIV-infected children at an earlier age and stage of disease progression so they can enroll in HIV care and treatment programs prior to becoming eligible for ART and these deaths can be prevented.
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