ArticlePloS one2011
Catechol-O-methyltransferase Val158Met polymorphism associates with individual differences in sleep physiologic responses to chronic sleep loss.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Common variants in DRD2 are associated with sleep duration: the CARe consortium.Human molecular genetics · 2016Pooled it
- Effects of COMT genotype and tolcapone on lapses of sustained attention after sleep deprivation in healthy young men.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Cognitive workload and sleep restriction interact to influence sleep homeostatic responses.Sleep · 2014Trial
- The COMT rs4680 SNP participates in the regulation of the arousal threshold in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2026Observational
- Association of Genetic Variants, Such as the μ-Opioid Receptor 1 (Biomedicines · 2025Article
- Sleep loss suicidal ideation: the role of trait extraversion.Frontiers in behavioral neuroscience · 2022Article
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- Sleep in the United States Military.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- On-orbit sleep problems of astronauts and countermeasures.Military Medical Research · 2018Review
- Catechol-O-methyltransferase (COMT) genotype affects cognitive control during total sleep deprivation.Cortex; a journal devoted to the study of the nervous system and behavior · 2018Article
- Article
- Healthy Adults Display Long-Term Trait-Like Neurobehavioral Resilience and Vulnerability to Sleep Loss.Scientific reports · 2017Article
- Neurobehavioral Effects and Biomarkers of Sleep Loss in Healthy Adults.Current neurology and neuroscience reports · 2017Review
- Human and rat gut microbiome composition is maintained following sleep restriction.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Effects of partial sleep deprivation on slow waves during non-rapid eye movement sleep: A high density EEG investigation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016Article
- Article
- Article
- Cumulative neurobehavioral and physiological effects of chronic caffeine intake: individual differences and implications for the use of caffeinated energy products.Nutrition reviews · 2014Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe COMT Val158Met polymorphism modulates cortical dopaminergic catabolism, and predicts individual differences in prefrontal executive functioning in healthy adults and schizophrenic patients, and associates with EEG differences during sleep loss. We assessed whether the COMT Val158Met polymorphism was a novel marker in healthy adults of differential vulnerability to chronic partial sleep deprivation (PSD), a condition distinct from total sleep loss and one experienced by millions on a daily and persistent basis. METHODOLOGY/PRINCIPAL
findings20 Met/Met, 64 Val/Met, and 45 Val/Val subjects participated in a protocol of two baseline 10h time in bed (TIB) nights followed by five consecutive 4 h TIB nights. Met/Met subjects showed differentially steeper declines in non-REM EEG slow-wave energy (SWE)-the putative homeostatic marker of sleep drive-during PSD, despite comparable baseline SWE declines. Val/Val subjects showed differentially smaller increases in slow-wave sleep and smaller reductions in stage 2 sleep during PSD, and had more stage 1 sleep across nights and a shorter baseline REM sleep latency. The genotypes, however, did not differ in performance across various executive function and cognitive tasks and showed comparable increases in subjective and physiological sleepiness in response to chronic sleep loss. Met/Met genotypic and Met allelic frequencies were higher in whites than African Americans. CONCLUSIONS/SIGNIFICANCE: The COMT Val158Met polymorphism may be a genetic biomarker for predicting individual differences in sleep physiology-but not in cognitive and executive functioning-resulting from sleep loss in a healthy, racially-diverse adult population of men and women. Beyond healthy sleepers, our results may also provide insight for predicting sleep loss responses in patients with schizophrenia and other psychiatric disorders, since these groups repeatedly experience chronically-curtailed sleep and demonstrate COMT-related treatment responses and risk factors for symptom exacerbation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.