ArticlePloS one2011
Loops determine the mechanical properties of mitotic chromosomes.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- An experimentally-informed polymer model reveals high resolution organization of genomic loci.Nature communications · 2026Article
- Motorized chromosome models of mitotic chromosome folding.Nature communications · 2025Article
- Bridging-mediated compaction of mitotic chromosomes.Nucleus (Austin, Tex.) · 2025Review
- Emerging mechanomedicines informed by mechanotransduction along the integrin-cytoskeleton-nucleus axis.APL bioengineering · 2025Review
- Article
- Structural reorganization and relaxation dynamics of axially stressed chromosomes.Biophysical journal · 2023Article
- Lattice simulation-based diffusion modelling of 3D chromatin structure.Computational and structural biotechnology journal · 2022Article
- Heterogeneous Loop Model to Infer 3D Chromosome Structures from Hi-C.Biophysical journal · 2019Article
- Chromosome Compaction by Active Loop Extrusion.Biophysical journal · 2016Article
- Article
- Article
- DNA double-strand breaks: linking gene expression to chromosome morphology and mobility.Chromosoma · 2014Article
- Organization of the mitotic chromosome.Science (New York, N.Y.) · 2013Article
- Article
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2 authors.
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Abstract
We introduce a new polymer model for mitotic chromosomes. The key assumption of the model is the ability of the chromatin fibre to cross-link to itself due to binding proteins. These protein-chromatin interactions are included by a probabilistic and dynamic mechanism. The hypothesis is motivated by the observation of high repulsive forces between ring polymers. We performed computer simulations to validate our model. Our results show that the presence of loops leads to a tight compaction and contributes significantly to the bending rigidity of chromosomes. Moreover, our qualitative prediction of the force elongation behaviour is close to experimental findings. The Dynamic Loop Model presented here indicates that the internal structure of mitotic chromosomes is based on self-organization of the chromatin fibre rather than attachment of chromatin to a protein scaffold. It also shows that the number and size of loops have a strong influence on the mechanical properties. We suggest that changes in the mechanical characteristics of chromosomes in different stages of the cell cycle, for example, can be explained by an altered internal loop structure.
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