ArticlePloS one2011
Periodic active case finding for TB: when to look?
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Increased Case Notification through Active Case Finding of Tuberculosis among Household and Neighbourhood Contacts in Cambodia.PloS one · 2016Trial
- Potential impact, costs, and benefits of population-wide screening interventions for tuberculosis in Viet Nam: A mathematical modelling study.PLOS global public health · 2025Article
- Community-based active-case finding for tuberculosis: navigating a complex minefield.BMC global and public health · 2024Review
- Cost of inaction: a framework to estimate the economic cost of missing a patient with tuberculosis in the Indian context.BMJ open · 2023Article
- Transmission modeling to infer tuberculosis incidence prevalence and mortality in settings with generalized HIV epidemics.Nature communications · 2023Article
- Impact of active case-finding for tuberculosis on case-notifications in Blantyre, Malawi: A community-based cluster-randomised trial (SCALE).PLOS global public health · 2023Article
- Costs and cost-effectiveness of a comprehensive tuberculosis case finding strategy in Zambia.PloS one · 2021Article
- A yield and cost comparison of tuberculosis contact investigation and intensified case finding in Uganda.PloS one · 2020Article
- A Pilot Project of Systematic Tuberculosis Screening in the Elderly in a South Korean Province.Tuberculosis and respiratory diseases · 2019Article
- High Yield of Active Tuberculosis Case Finding Among HIV-Infected Patients Using Xpert MTB/RIF Testing.Open forum infectious diseases · 2019Article
- Disparities in access to diagnosis and care in Blantyre, Malawi, identified through enhanced tuberculosis surveillance and spatial analysis.BMC medicine · 2019Article
- Factors affecting tuberculosis health message recall 2 years after active case finding in Blantyre, Malawi.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2018Article
- Bridging the gap between evidence and policy for infectious diseases: How models can aid public health decision-making.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2016Review
- How can mathematical models advance tuberculosis control in high HIV prevalence settings?The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2014Review
- Tuberculosis screening in high human immunodeficiency virus prevalence settings: turning promise into reality.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2013Review
- Identifying dynamic tuberculosis case-finding policies for HIV/TB coepidemics.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveTo investigate the factors influencing the performance and cost-efficacy of periodic rounds of active case finding (ACF) for TB.
methodsA mathematical model of TB dynamics and periodic ACF (PACF) in the HIV era, simplified by assuming constant prevalence of latent TB infection, is analyzed for features that control intervention outcome, measured as cases averted and cases found. Explanatory variables include baseline TB incidence, interval between PACF rounds, and different routine and PACF case-detection rates among HIV-infected and uninfected TB cases.
findingsPACF can be cost-saving over a 10 year time frame if the cost-per-round is lower than a threshold proportional to initial incidence and cost-per-case-treated. More cases are averted at higher baseline incidence rates, when more potent PACF strategies are used, intervals between PACF rounds are shorter, and when the ratio of HIV-negative to positive TB cases detected is higher. More costly approaches, e.g. radiographic screening, can be as cost-effective as less costly alternatives if PACF case-detection is higher and/or implementation less frequent.
conclusionPeriodic ACF can both improve control and save medium-term health care costs in high TB burden settings. Greater costs of highly effective PACF at frequent (e.g. yearly) intervals may be offset by higher numbers of cases averted in populations with high baseline TB incidence, higher prevalence of HIV-uninfected cases, higher costs per-case-treated, and more effective routine case-detection. Less intensive approaches may still be cost-neutral or cost-saving in populations lacking one or more of these key determinants.
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