ArticlePloS one2011
Zebrafish prox1b mutants develop a lymphatic vasculature, and prox1b does not specifically mark lymphatic endothelial cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice.International journal of molecular sciences · 2024Article
- Lymphatic Defects in ZebrafishCells · 2023Article
- Single-cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development.The EMBO journal · 2023Article
- The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation in the zebrafish trunk.Angiogenesis · 2021Article
- Mechanisms and cell lineages in lymphatic vascular development.Angiogenesis · 2021Review
- Formation and Growth of Cardiac Lymphatics during Embryonic Development, Heart Regeneration, and Disease.Cold Spring Harbor perspectives in biology · 2020Review
- Cellular Origins of the Lymphatic Endothelium: Implications for Cancer Lymphangiogenesis.Frontiers in physiology · 2020Review
- ETS transcription factor Etsrp / Etv2 is required for lymphangiogenesis and directly regulates vegfr3 / flt4 expression.Developmental biology · 2018Article
- Divergence of zebrafish and mouse lymphatic cell fate specification pathways.Development (Cambridge, England) · 2014Article
- Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos.Circulation research · 2014Article
- A transgenic Xenopus laevis reporter model to study lymphangiogenesis.Biology open · 2013Article
- Immunohistochemical demonstration of lymphatic vessels in adult zebrafish.Acta histochemica et cytochemica · 2012Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe expression of the Prospero homeodomain transcription factor (Prox1) in a subset of cardinal venous cells specifies the lymphatic lineage in mice. Prox1 is also indispensible for the maintenance of lymphatic cell fate, and is therefore considered a master control gene for lymphangiogenesis in mammals. In zebrafish, there are two prox1 paralogues, the previously described prox1 (also known as prox1a) and the newly identified prox1b. PRINCIPAL
findingsTo investigate the role of the prox1b gene in zebrafish lymphangiogenesis, we knocked-down prox1b and found that depletion of prox1b mRNA did not cause lymphatic defects. We also generated two different prox1b mutant alleles, and maternal-zygotic homozygous mutant embryos were viable and did not show any lymphatic defects. Furthermore, the expression of prox1b was not restricted to lymphatic vessels during zebrafish development.
conclusionWe conclude that Prox1b activity is not essential for embryonic lymphatic development in zebrafish.
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