ArticlePloS one2011
Improved culture-based isolation of differentiating endothelial progenitor cells from mouse bone marrow mononuclear cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Exosomes derived from BMSCs in osteogenic differentiation promote type H blood vessel angiogenesis through miR-150-5p mediated metabolic reprogramming of endothelial cells.Cellular and molecular life sciences : CMLS · 2024Article
- Bone Marrow-Derived Vasculogenic Mesenchymal Stem Cells Enhance In Vitro Angiogenic Sprouting of Human Umbilical Vein Endothelial Cells.International journal of molecular sciences · 2022Article
- miR-188-3p targets skeletal endothelium coupling of angiogenesis and osteogenesis during ageing.Cell death & disease · 2022Article
- The Effects of SRT1720 Treatment on Endothelial Cells Derived from the Lung and Bone Marrow of Young and Aged, Male and Female Mice.International journal of molecular sciences · 2021Article
- A Novel Hypothesis and Characterization to Isolate Microvascular Endothelial Cells Simultaneously with Adipose-Derived Stem Cells from the Human Adipose-Derived Stromal Vascular Fraction.Tissue engineering and regenerative medicine · 2021Article
- Article
- Effects of hypoxic-ischemic pre-treatment on microvesicles derived from endothelial progenitor cells.Experimental and therapeutic medicine · 2020Article
- Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs.Journal of cell communication and signaling · 2019Article
- Rhynchophylline Attenuates Senescence of Endothelial Progenitor Cells by Enhancing Autophagy.Frontiers in pharmacology · 2019Article
- Ghrelin Stimulates Endothelial Cells Angiogenesis through Extracellular Regulated Protein Kinases (ERK) Signaling Pathway.International journal of molecular sciences · 2018Article
- Reduction of Endoplasmic Reticulum Stress Improves Angiogenic Progenitor Cell function in a Mouse Model of Type 1 Diabetes.Cell death & disease · 2018Article
- Whole-Transcriptome Sequencing: a Powerful Tool for Vascular Tissue Engineering and Endothelial Mechanobiology.High-throughput · 2018Review
- CXCR-4 expression by circulating endothelial progenitor cells and SDF-1 serum levels are elevated in septic patients.Journal of inflammation (London, England) · 2018Article
- Curcumin induces therapeutic angiogenesis in a diabetic mouse hindlimb ischemia model via modulating the function of endothelial progenitor cells.Stem cell research & therapy · 2017Article
- Skeletal Colonization by Breast Cancer Cells Is Stimulated by an Osteoblast and β2AR-Dependent Neo-Angiogenic Switch.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Inhibitor of DNA binding 1 regulates cell cycle progression of endothelial progenitor cells through induction of Wnt2 expression.Molecular medicine reports · 2016Article
- Androgen Modulates Functions of Endothelial Progenitor Cells through Activated Egr1 Signaling.Stem cells international · 2016Article
- Loss of endothelial-ARNT in adult mice contributes to dampened circulating proangiogenic cells and delayed wound healing.Vascular medicine (London, England) · 2014Article
- Mouse bone marrow-derived endothelial progenitor cells do not restore radiation-induced microvascular damage.ISRN cardiology · 2014Article
- Maturing EPCs into endothelial cells: may the force be with the EPCs: focus on "Fluid shear stress induces differentiation of circulating phenotype endothelial progenitor cells".American journal of physiology. Cell physiology · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous endothelial progenitor cell (EPC)-related investigations have been performed in mouse experiments. However, defined characteristics of mouse cultured EPC have not been examined. We focused on fast versus slow adherent cell population in bone marrow mononuclear cells (BMMNCs) in culture and examined their characteristics. After 24 h-culture of BMMNCs, attached (AT) cells and floating (FL) cells were further cultured in endothelial differentiation medium separately. Immunological and molecular analyses exhibited more endothelial-like and less monocyte/macrophage-like characteristics in FL cells compared with AT cells. FL cells formed thick/stable tube and hypoxia or shear stress overload further enhanced these endothelial-like features with increased angiogenic cytokine/growth factor mRNA expressions. Finally, FL cells exhibited therapeutic potential in a mouse myocardial infarction model showing the specific local recruitment to ischemic border zone and tissue preservation. These findings suggest that slow adherent (FL) but not fast attached (AT) BMMNCs in culture are EPC-rich population in mouse.
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