ArticleWorld journal of gastroenterology2011
Helicobacter pylori's virulence and infection persistence define pre-eclampsia complicated by fetal growth retardation.
Article in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Gestational Antibodies to C. pneumoniae, H. pylori and CMV in Women with Preeclampsia and in Matched Controls.Maternal and child health journal · 2022Article
- Magnitude ofInternational journal of women's health · 2022Article
- The effects ofAnnals of translational medicine · 2021Article
- Role of the Macrophage Migration Inhibitory Factor in the Pathophysiology of Pre-Eclampsia.International journal of molecular sciences · 2021Review
- "The Flea Catcher" portrait: does it image pre-eclampsia or hypothyroidism?Journal of endocrinological investigation · 2020Article
- Maternal H. pylori seropositivity is associated with gestational hypertension but is irrelevant to fetal growth and development in early childhood.BMC pediatrics · 2019Article
- Protection from Preeclampsia.Chinese medical journal · 2018Article
- Symptom severity in autism spectrum disorder is related to the frequency and severity of nausea and vomiting during pregnancy: a retrospective case-control study.Molecular autism · 2018Article
- Human infectious diseases and risk of preeclampsia: an updated review of the literature.Infection · 2017Review
- O Blood Group as a Risk Factor forClinics and practice · 2017Article
- Anti-phospholipid syndrome therapy.Internal and emergency medicine · 2017Article
- Helicobacter pylori colonization and pregnancies complicated by preeclampsia, spontaneous prematurity, and small for gestational age birth.Helicobacter · 2017Article
- Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father.Frontiers in medicine · 2017Article
- Effect of maternalThe Pan African medical journal · 2017Article
- Effect of maternal Helicobacter Pylori infection on birth weight in an urban community in Uganda.BMC pregnancy and childbirth · 2016Article
- Association of Helicobacter Pylori Infection and Ectopic Pregnancy.Journal of family & reproductive health · 2016Article
- Helicobacter pylori in children with asthmatic conditions at school age, and their mothers.Alimentary pharmacology & therapeutics · 2016Article
- A Dormant Microbial Component in the Development of Preeclampsia.Frontiers in medicine · 2016Review
- Beyond the stomach: an updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment.World journal of gastroenterology · 2014Review
- Can Helicobacter pylori infection influence human reproduction?World journal of gastroenterology · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo better understand the pathogenic role of Helicobacter pylori (H. pylori) in pre-eclampsia (PE), and whether it is associated or not with fetal growth retardation (FGR).
methodsMaternal blood samples were collected from 62 consecutive pregnant women with a diagnosis of PE and/or FGR, and from 49 women with uneventful pregnancies (controls). Serum samples were evaluated by immunoblot assay for presence of specific antibodies against H. pylori antigens [virulence: cytotoxin-associated antigen A (CagA); ureases; heat shock protein B; flagellin A; persistence: vacuolating cytotoxin A (VacA)]. Maternal complete blood count and liver enzymes levels were assessed at delivery by an automated analyzer.
resultsA significantly higher percentage of H. pylori seropositive women were found among PE cases (85.7%) compared to controls (42.9%, P < 0.001). There were no differences between pregnancies complicated by FGR without maternal hypertension (46.2%) and controls. Importantly, persistent and virulent infections (VacA/CagA seropositive patients, intermediate leukocyte blood count and aspartate aminotransferase levels) were exclusively associated with pre-eclampsia complicated by FGR, while virulent but acute infections (CagA positive/VacA negative patients, highest leukocyte blood count and aspartate aminotransferase levels) specifically correlated with PE without FGR.
conclusionOur data strongly indicate that persistent and virulent H. pylori infections cause or contribute to PE complicated by FGR, but not to PE without feto-placental compromise.
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Registered trials
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