Evidence map›Paper›PMID 22215923›Full record

ArticleSleep2012

A prospective study of sleep duration and pneumonia risk in women.

Sanjay R Patel, Atul Malhotra, Xiang Gao, Frank B Hu, Mark I Neuman, Wafaie W Fawzi

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Sleep, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02887209 (A Pragmatic Pilot Study of Cognitive Behavioural Therapy for Insomnia Among People Living With HIV), which is not on this map. Cited by 100 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 4 pooled it
6.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02887209 nacompletednot on this mapstarted 2016, after this paper: background citation

A Pragmatic Pilot Study of Cognitive Behavioural Therapy for Insomnia Among People Living With HIV

TypeinterventionalSponsorToronto Metropolitan UniversityRan2016 to 2018Enrolled10ConditionsInsomnia, HIVArmsCBT-I
3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 4 syntheses or guidelines pooled it, 194 citations in OpenAlex.

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  16. Individual associations of self-reported sleep duration, sleep quality, chronotype and social jet lag with infectious disease risk.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Sanjay R PatelDivision of Sleep Medicine, Brigham and Women’s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA. spatel@partners.org
Atul Malhotra
Xiang Gao
Frank B Hu
Mark I Neuman
Wafaie W Fawzi
Brigham and Women's Hospital · USHarvard University · USBoston Children's Hospital · USHarvard Global Health Institute · US

Funding

Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
Wakefulness and Forebrain Activation by Orexin NeuronsP01HL095491 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHAMBERLIN, NANCY L · 2010 to 2019
$25.1M
Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea PathogenesisR01HL085188 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2008 to 2018
$3.5M
Mechanisms Underlying the Aging Predisposition to Obstructive Sleep ApneaR01HL090897 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MALHOTRA, ATUL · 2009 to 2012
$1.8M
Sleep Apnea and Obesity: Cardiovascular Risk AssessmentR01HL073146 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MALHOTRA, ATUL · 2003 to 2008
$1.6M
Assessment of Upper Airway Mechanics Using Newer EMG TechniquesK24HL093218 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2009 to 2013
$857k
The Genetics of Metabolic Dysfunction in Sleep ApneaK08HL081385 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI PATEL, SANJAY R · 2005 to 2009
$670k
NCI NIH HHS CA50385NCI NIH HHS R01 CA050385NHLBI NIH HHS HL081385NHLBI NIH HHS HL085188NHLBI NIH HHS HL090897NHLBI NIH HHS HL093218NHLBI NIH HHS HL73146NHLBI NIH HHS K08 HL081385NHLBI NIH HHS K24 HL093218NHLBI NIH HHS P01 HL095491NHLBI NIH HHS R01 HL073146NHLBI NIH HHS R01 HL085188NHLBI NIH HHS R01 HL090897
6 · The paper itself

Abstract

STUDY

objectiveExperimental data suggest sleep deprivation may impair host immunity. We sought to assess the effect of poor sleep on pneumonia risk.

designProspective, observational cohort study.

participants56,953 female nurses (ages 37 to 57 years old) participating in the Nurses' Health Study II cohort free of cancer, cardiovascular disease, diabetes, and asthma with no prior history of pneumonia. MEASUREMENTS AND

resultsAt baseline, participants reported their average sleep duration and whether this quantity was adequate for them. Questionnaires ascertaining a new pneumonia diagnosis were mailed every 2 years. Cases required physician diagnosis and chest radiograph confirmation. Cox proportional hazards models were used to assess the relative risk for incident pneumonia over 4 years. Over 217,500 person-years, 977 cases of pneumonia were identified. Relative to 8-h sleepers, both short and long sleep durations were associated with elevated pneumonia risk. The age-adjusted relative risk for pneumonia was 1.70 (95% CI 1.30-2.23) in those sleeping ≤ 5 h and 1.49 (95% CI 1.12-1.98) in those sleeping ≥ 9 h. After adjusting for potential confounders, the relative risks were 1.39 (95% CI: 1.06-1.82) in those sleeping ≤ 5 h and 1.38 (95% CI 1.04-1.84) in those sleeping ≥ 9 h. Perceived inadequate sleep was also associated with pneumonia with a relative risk of 1.50 (95% CI 1.29-1.74) in multivariate models.

conclusionsBoth reduced and prolonged habitual sleep durations are associated with increased risk of pneumonia. Further research is needed to understand how sleep habits can influence immunity.

Indexed as

AdultAge FactorsFemaleHumansMiddle AgedPneumoniaProportional Hazards ModelsProspective StudiesRisk FactorsSleepSleep DeprivationTime FactorsinfectionpneumoniaSleepsleep deprivation

Identifiers

PMID22215923
PMCPMC3242694
OpenAlexW2035535447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.