ArticleCirculation. Arrhythmia and electrophysiology2012
Functional nature of electrogram fractionation demonstrated by left atrial high-density mapping.
Article in Circulation. Arrhythmia and electrophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 139 citations in OpenAlex.
- Comparative distribution of complex fractionated atrial electrograms, high dominant frequency (HDF) sites during atrial fibrillation and HDF sites during sinus rhythm.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2013Trial
- Outcomes of Functional Substrate Mapping Based Ablation in Addition to Pulmonary Vein Isolation in Atrial Fibrillation.Pacing and clinical electrophysiology : PACE · 2026Article
- Functional mapping identifies early arrhythmogenic substrate in recurrent atrial fibrillation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Functional Substrate Mapping of the Right Atrium: A Novel Method to Identify Critical Isthmus of Re-entry in Atrial Tachycardia.The Journal of innovations in cardiac rhythm management · 2025Article
- Electrophysiological Findings in Patients with Early Recurrence During Blanking Period Following Atrial Fibrillation Ablation.Anatolian journal of cardiology · 2025Article
- Atrial Cardiomyopathy: From Diagnosis to Treatment.Reviews in cardiovascular medicine · 2025Review
- Influence of Heart Rate and Change in Wavefront Direction through Pacing on Conduction Velocity and Voltage Amplitude in a Porcine Model: A High-Density Mapping Study.Journal of personalized medicine · 2024Article
- Identification of Atrial Transmural Conduction Inhomogeneity Using Unipolar Electrogram Morphology.Journal of clinical medicine · 2024Article
- Vector Field Heterogeneity for the Assessment of Locally Disorganised Cardiac Electrical Propagation Wavefronts From High-Density Multielectrodes.IEEE open journal of engineering in medicine and biology · 2024Article
- Functional mapping to reveal slow conduction and substrate progression in atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Construction and integrated analysis of the ceRNA network hsa_circ_0000672/miR-516a-5p/TRAF6 and its potential function in atrial fibrillation.Scientific reports · 2023Article
- Comparing the efficacy of catheter ablation strategies for persistent atrial fibrillation: a Bayesian analysis of randomized controlled trials.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023Review
- Comparison of clinical outcomes of Ibutilide-guided cardioversion and direct current synchronized cardioversion after radiofrequency ablation of persistent atrial fibrillation.Frontiers in cardiovascular medicine · 2023Article
- High-density mapping of the average complex interval helps localizing atrial fibrillation drivers and predicts catheter ablation outcomes.Frontiers in cardiovascular medicine · 2023Article
- Fixed complex electrograms during sinus rhythm and local pacing: potential ablation targets for persistent atrial fibrillation.Scientific reports · 2022Article
- Atrial Fibrillation and Acute Ischemic Stroke: Evaluation of the Contemporary 2018 National Inpatient Sample Database.CJC open · 2022Article
- Catheter Ablation in Persistent AF, the Evolution towards a More Pragmatic Strategy.Journal of clinical medicine · 2021Review
- Association Between the Coronary Sinus Ostial Size and Atrioventricular Nodal Reentrant Tachycardia in Patients With Pulmonary Arterial Hypertension.Frontiers in physiology · 2021Article
- Revealing hidden information from unipolar extracellular potentials.HeartRhythm case reports · 2020Article
- Multilayer fabrication of durable catheter-deployable soft robotic sensor arrays for efficient left atrial mapping.Science advances · 2020Article
Corrections and comments
- Commented on by
Authors and funding
20 authors at 1 institution in 1 country.
Funding
Abstract
backgroundComplex fractionated atrial electrograms (CFAE) are targets of atrial fibrillation (AF) ablation. Serial high-density maps were evaluated to understand the impact of activation direction and rate on electrogram (EGM) fractionation. METHODS AND
resultsEighteen patients (9 persistent) underwent high-density, 3-dimensional, left-atrial mapping (>400 points/map) during AF, sinus (SR), and CS-paced (CSp) rhythms. In SR and CSp, fractionation was defined as an EGM with ≥4 deflections, although, in AF, CFE-mean <80 ms was considered as continuous CFAE. The anatomic distribution of CFAE sites was assessed, quantified, and correlated between rhythms. Mechanisms underlying fractionation were investigated by analysis of voltage, activation, and propagation maps. A minority of continuous CFAE sites displayed EGM fractionation in SR (15+/-4%) and CSp (12+/-8%). EGM fractionation did not match between SR and CSp at 70+/-10% sites. Activation maps in SR and CSp showed that wave collision (71%) and regional slow conduction (24%) caused EGM fractionation. EGM voltage during AF (0.59+/-0.58 mV) was lower than during SR and CSp (>1.0 mV) at all sites. During AF, the EGM voltage was higher at continuous CFAE sites than at non-CFAE sites (0.53 mV (Q1, Q3: 0.33 to 0.83) versus 0.30 mV (Q1, Q3: 0.18 to 0.515), P<0.00001). Global LA voltage in AF was lower in patients with persistent AF versus patients with paroxysmal AF (0.6+/-0.59 mV versus 1.12+/-1.32 mV, P<0.01).
conclusionsThe distribution of fractionated EGMs is highly variable, depending on direction and rate of activation (SR versus CSp versus AF). Fractionation in SR and CSp rhythms mostly resulted from wave collision. All sites with continuous fractionation in AF displayed normal voltage in SR, suggesting absence of structural scar. Thus, many fractionated EGMs are functional in nature, and their sites dynamic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.