ArticleJournal of lipid research2012
Obesity and altered glucose metabolism impact HDL composition in CETP transgenic mice: a role for ovarian hormones.
Article in Journal of lipid research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- ApoC3 is expressed in oocytes and increased expression is associated with PCOS progression.Journal of ovarian research · 2023Article
- Gut microbiota and butyrate contribute to nonalcoholic fatty liver disease in premenopause due to estrogen deficiency.PloS one · 2022Article
- Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males.Cell reports · 2021Article
- Expressing the Human Cholesteryl Ester Transfer Protein Minigene Improves Diet-Induced Fatty Liver and Insulin Resistance in Female Mice.Frontiers in physiology · 2021Article
- EPHB2 carried on small extracellular vesicles induces tumor angiogenesis via activation of ephrin reverse signaling.JCI insight · 2019Article
- HDL subclass proteomic analysis and functional implication of protein dynamic change during HDL maturation.Redox biology · 2019Article
- Tea Seed Oil Prevents Obesity, Reduces Physical Fatigue, and Improves Exercise Performance in High-Fat-Diet-Induced Obese Ovariectomized Mice.Molecules (Basel, Switzerland) · 2019Article
- Negative regulation of Candida glabrata Pdr1 by the deubiquitinase subunit Bre5 occurs in a ubiquitin independent manner.Molecular microbiology · 2018Article
- Regulation of energy rheostasis by the melanocortin-3 receptor.Science advances · 2018Article
- Hepatocyte estrogen receptor alpha mediates estrogen action to promote reverse cholesterol transport during Western-type diet feeding.Molecular metabolism · 2018Article
- Estrogen deprivation aggravates cardiac hypertrophy in nonobese Type 2 diabetic Goto-Kakizaki (GK) rats.Bioscience reports · 2017Article
- Chromosomal abnormalities and molecular landscape of metastasizing mucinous salivary adenocarcinoma.Oral oncology · 2017Article
- Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation.Development (Cambridge, England) · 2016Article
- Cortactin promotes exosome secretion by controlling branched actin dynamics.The Journal of cell biology · 2016Article
- Antagonistic roles for the ubiquitin ligase Asr1 and the ubiquitin-specific protease Ubp3 in subtelomeric gene silencing.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Alteration of the Helicobacter pylori membrane proteome in response to changes in environmental salt concentration.Proteomics. Clinical applications · 2015Article
- Article
- Enhancer of Rudimentary Homolog Affects the Replication Stress Response through Regulation of RNA Processing.Molecular and cellular biology · 2015Article
- P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.Oncogene · 2015Article
- Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet β cells.Cell reports · 2015Article
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Authors and funding
12 authors at 5 institutions in 4 countries.
Funding
Abstract
Mechanisms underlying changes in HDL composition caused by obesity are poorly defined, partly because mice lack expression of cholesteryl ester transfer protein (CETP), which shuttles triglyceride and cholesteryl ester between lipoproteins. Because menopause is associated with weight gain, altered glucose metabolism, and changes in HDL, we tested the effect of feeding a high-fat diet (HFD) and ovariectomy (OVX) on glucose metabolism and HDL composition in CETP transgenic mice. After OVX, female CETP-expressing mice had accelerated weight gain with HFD-feeding and impaired glucose tolerance by hyperglycemic clamp techniques, compared with OVX mice fed a low-fat diet (LFD). Sham-operated mice (SHAM) did not show HFD-induced weight gain and had less glucose intolerance than OVX mice. Using shotgun HDL proteomics, HFD-feeding in OVX mice had a large effect on HDL composition, including increased levels of apoA2, apoA4, apoC2, and apoC3, proteins involved in TG metabolism. These changes were associated with decreased hepatic expression of SR-B1, ABCA1, and LDL receptor, proteins involved in modulating the lipid content of HDL. In SHAM mice, there were minimal changes in HDL composition with HFD feeding. These studies suggest that the absence of ovarian hormones negatively influences the response to high-fat feeding in terms of glucose tolerance and HDL composition. CETP-expressing mice may represent a useful model to define how metabolic changes affect HDL composition and function.
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