ArticleHypertension (Dallas, Tex. : 1979)2012
Chronic intrarenal insulin replacement reverses diabetes mellitus-induced natriuresis and diuresis.
Article in Hypertension (Dallas, Tex. : 1979), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Early-Life Stress Programs a Vulnerable Renal Phenotype Under Metabolic Challenge in a Murine Model.Biomolecules · 2026Article
- The damaging duo: Obesity and excess dietary salt contribute to hypertension and cardiovascular disease.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Review
- Postprandial effects on electrolyte homeostasis in the kidney.American journal of physiology. Renal physiology · 2019Review
- Increased ENaC activity during kidney preservation in Wisconsin solution.BMC nephrology · 2019Article
- Physiological hyperinsulinemia caused by acute hyperglycemia minimizes renal sodium loss by direct action on kidneys.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Chronic renal artery insulin infusion increases mean arterial pressure in male Sprague-Dawley rats.American journal of physiology. Renal physiology · 2018Article
- The normal increase in insulin after a meal may be required to prevent postprandial renal sodium and volume losses.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Resistance to insulin and kidney disease in the cardiorenal metabolic syndrome; role for angiotensin II.Molecular and cellular endocrinology · 2013Review
- Regulation of ENaC in mice lacking renal insulin receptors in the collecting duct.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Sodium-retaining effect of insulin in diabetes.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We showed recently that sustained natriuresis in type 1 diabetic dogs was attributed to the decrease in insulin rather than the hyperglycemia alone. The sodium-retaining action of insulin appeared to require hyperglycemia, and it completely reversed the diabetic natriuresis and diuresis. This study tested whether the sodium-retaining effect was attributed to direct intrarenal actions of insulin. Alloxan-treated dogs (D; n=7) were maintained normoglycemic using 24-h/d IV insulin replacement. After control measurements, IV insulin was decreased to begin a 6-day diabetic period. Blood glucose increased from 84±6 mg/dL to an average of 428 mg/dL on days 5 and 6, sodium excretion increased from 74±8 to 98±7 meq/d over the 6 days, and urine volume increased from 1645±83 to 2198±170 mL/d. Dir dogs (n=7) were subjected to the same diabetic regimen, but, in addition, insulin was infused continuously into the renal artery at 0.3 mU/kg per minute during the 6-day period. This did not affect plasma insulin. Blood glucose increased from 94±10 mg/dL to an average of 380 mg/dL on days 5 and 6, but sodium excretion averaged 76±5 and 69±8 meq/d during control and diabetes mellitus, respectively. The diuresis also was prevented. Glomerular filtration rate increased only in Dir dogs, and there was no change in mean arterial pressure in either group. This intrarenal insulin infusion had no effect on sodium or volume excretion in normal dogs. Intrarenal insulin replacement in diabetic dogs caused a sustained increase in tubular reabsorption that completely reversed diabetic natriuresis. Insulin plus glucose may work to prevent salt wasting in uncontrolled type 2 diabetes mellitus.
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