ArticleHuman reproduction (Oxford, England)2012
Occupational exposure to chemicals and fetal growth: the Generation R Study.
Article in Human reproduction (Oxford, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.Frontiers in neuroscience · 2021Pooled it
- Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis.Environmental health perspectives · 2016Pooled it
- Maternal exposure to di-2-ethylhexylphthalate and adverse delivery outcomes: A systematic review.Reproductive toxicology (Elmsford, N.Y.) · 2016Pooled it
- Multiple maternal occupational exposures during pregnancy and newborn size at birth: analysis of the ELFE cohort, a French longitudinal study of children.Scandinavian journal of work, environment & health · 2026Article
- Prenatal methylmercury exposure disrupts developmental trajectories and induces sex-specific toxicity in pubertal rats.Research square · 2026Article
- Polycyclic aromatic hydrocarbons and perinatal outcomes: a scoping review.Pediatric research · 2026Review
- The Impact of Endocrine Disruptor Exposure During Pregnancy on Bacterial Complications and Viral Infections: A Narrative Review.Microorganisms · 2026Review
- Predictive value and mediating effect analysis of the AHR-ARNT-CYP1A1 axis for missed abortion related to polycyclic aromatic hydrocarbons exposure.Scientific reports · 2025Article
- EndoCompass Project: Environmental Endocrinology.Hormone research in paediatrics · 2025Review
- Maternal occupational exposures during early stages of pregnancy and adverse birth outcomes in the NINFEA birth-cohort.PloS one · 2025Article
- Exposure to Endocrine Disruptors in Early life and Neuroimaging Findings in Childhood and Adolescence: a Scoping Review.Current environmental health reports · 2024Article
- Longitudinal associations between urinary biomarkers of phthalates and replacements with novel in vivo measures of placental health.Human reproduction (Oxford, England) · 2024Article
- Chemical mixture that targets the epidermal growth factor pathway impairs human trophoblast cell functions.Toxicology and applied pharmacology · 2024Article
- Maternal occupational exposure to chemicals and child cognitive function.Pediatric research · 2022Article
- A Critical Review on the Complex Interplay between Social Determinants of Health and Maternal and Infant Mortality.Children (Basel, Switzerland) · 2022Review
- Association between Total and Individual PCB Congener Levels in Maternal Serum and Birth Weight of Newborns: Results from the Chiba Study of Mother and Child Health Using Weighted Quantile Sum Regression.International journal of environmental research and public health · 2022Article
- Article
- Phthalates exposure during pregnancy a study in a Mexican cohort.Toxicology reports · 2021Article
- Neonatal Outcomes in the MONEAD Study of Pregnant Women with Epilepsy.The journal of pediatrics: X · 2021Article
- Glyphosate Herbicide: Reproductive Outcomes and Multigenerational Effects.Frontiers in endocrinology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDevelopmental diseases, such as birth defects, growth restriction and preterm delivery, account for >25% of infant mortality and morbidity. Several studies have shown that exposure to chemicals during pregnancy is associated with adverse birth outcomes. The aim of this study was to identify whether occupational exposure to various chemicals might adversely influence intrauterine growth patterns and placental weight.
methodsAssociations between maternal occupational exposure to various chemicals and fetal growth were studied in 4680 pregnant women participating in a population-based prospective cohort study from early pregnancy onwards in the Netherlands (2002-2006), the Generation R Study. Mothers who filled out a questionnaire during mid-pregnancy (response: 77% of enrolment) were included if they conducted paid employment during pregnancy and had a spontaneously conceived singleton live born pregnancy (n = 4680). A job exposure matrix was used, linking job titles to expert judgement on exposure to chemicals in the workplace. Fetal growth characteristics were repeatedly measured by ultrasound and were used in combination with measurements at birth. Placental weight was obtained from medical records and hospital registries. Linear regression models for repeated measurements were used to study the associations between maternal occupational exposure to chemicals and intrauterine growth.
resultsWe observed that maternal occupational exposure to polycyclic aromatic hydrocarbons, phthalates, alkylphenolic compounds and pesticides adversely influenced several domains of fetal growth (fetal weight, fetal head circumference and fetal length). We found a significant association between pesticide and phthalate exposure with a decreased placental weight.
conclusionsOur results suggest that maternal occupational exposure to several chemicals is associated with impaired fetal growth during pregnancy and a decreased placental weight. Further studies are needed to confirm these findings and to assess post-natal consequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.