ArticleHuman reproduction (Oxford, England)2012
High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples.
Article in Human reproduction (Oxford, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Endometrial shedding effect on conception and live birth in women with polycystic ovary syndrome.Obstetrics and gynecology · 2012Trial
- Progesterone receptor, prokineticin 1, LncRNA-H19, and miR-210 in molecular regulation of recurrent implantation failure.Scientific reports · 2026Article
- The uterine secretome initiates growth of gynecologic tissues in ectopic locations: re-evaluating the evidence.Pathology oncology research : POR · 2026Review
- Microfluidic chip-integrated vascularized endometrial complexes: Mitochondrial function and paracrine crosstalk enhance regenerative potential.Bioactive materials · 2025Article
- The Efficacy of Vitamin D Supplement in the Expression and Protein Levels of Endometrial Decidualization Factors in Women with Recurrent Implantation Failure.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Single-cell transcriptome analysis reveals endometrial immune microenvironment in minimal/mild endometriosis.Clinical and experimental immunology · 2023Article
- Induction of the PPARγ (Peroxisome Proliferator-Activated Receptor γ)-GCM1 (Glial Cell Missing 1) Syncytialization Axis Reduces sFLT1 (Soluble fms-Like Tyrosine Kinase 1) in the Preeclamptic Placenta.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Evaluation of Expression and Phosphorylation of Progesterone Receptor in Endometrial Stromal Cells of Patients with Recurrent Implantation Failure Compared to Healthy Fertile Women.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Rosiglitazone blocks first trimester in-vitro placental injury caused by NF-κB-mediated inflammation.Scientific reports · 2019Article
- Extraembryonic heparin-binding epidermal growth factor-like growth factor deficiency compromises placentation in mice.Biology of reproduction · 2019Article
- Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding.Cell death and differentiation · 2017Article
- Enhancement of trophoblast differentiation and survival by low molecular weight heparin requires heparin-binding EGF-like growth factor.Human reproduction (Oxford, England) · 2017Article
- Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome.EBioMedicine · 2017Article
- Reduced homeobox protein MSX1 in human endometrial tissue is linked to infertility.Human reproduction (Oxford, England) · 2016Article
- MicroRNA Profiles in Spontaneous Decidualized Menstrual Endometrium and Early Pregnancy Decidua with Successfully Implanted Embryos.PloS one · 2016Article
- Sildenafil stimulates human trophoblast invasion through nitric oxide and guanosine 3',5'-cyclic monophosphate signaling.Fertility and sterility · 2015Article
- Changes in receptivity epithelial cell markers of endometrium after ovarian stimulation treatments: its role during implantation window.Reproductive health · 2015Article
- Article
- Cell signaling in trophoblast-uterine communication.The International journal of developmental biology · 2014Review
- Differential expression of serum glycodelin and insulin-like growth factor binding protein 1 in early pregnancy.Reproductive sciences (Thousand Oaks, Calif.) · 2013Article
Corrections and comments
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Authors and funding
17 authors at 12 institutions in 1 country.
Funding
Abstract
backgroundAlthough histological dating of endometrial biopsies provides little help for prediction or diagnosis of infertility, analysis of individual endometrial proteins, proteomic profiling and transcriptome analysis have suggested several biomarkers with altered expression arising from intrinsic abnormalities, inadequate stimulation by or in response to gonadal steroids or altered function due to systemic disorders. The objective of this study was to delineate the developmental dynamics of potentially important proteins in the secretory phase of the menstrual cycle, utilizing a collection of endometrial biopsies from women of fertile (n = 89) and infertile (n = 89) couples. METHODS AND
resultsProgesterone receptor-B (PGR-B), leukemia inhibitory factor, glycodelin/progestagen-associated endometrial protein (PAEP), homeobox A10, heparin-binding EGF-like growth factor, calcitonin and chemokine ligand 14 (CXCL14) were measured using a high-throughput, quantitative immunohistochemical method. Significant cyclic and tissue-specific regulation was documented for each protein, as well as their dysregulation in women of infertile couples. Infertile patients demonstrated a delay early in the secretory phase in the decline of PGR-B (P < 0.05) and premature mid-secretory increases in PAEP (P < 0.05) and CXCL14 (P < 0.05), suggesting that the implantation interval could be closing early. Correlation analysis identified potential interactions among certain proteins that were disrupted by infertility.
conclusionsThis approach overcomes the limitations of a small sample number. Protein expression and localization provided important insights into the potential roles of these proteins in normal and pathological development of the endometrium that is not attainable from transcriptome analysis, establishing a basis for biomarker, diagnostic and targeted drug development for women with infertility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.