ArticleJournal of biological rhythms2011
Daily rhythms in olfactory discrimination depend on clock genes but not the suprachiasmatic nucleus.
Article in Journal of biological rhythms, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Time of day alters olfactory bulb immune state with ramifications for intranasal inflammatory challenge.Cell reports · 2026Article
- Brain circadian clocks timing the 24h rhythms of behavior.Npj biological timing and sleep · 2025Review
- Circadian rhythm mechanism in the suprachiasmatic nucleus and its relation to the olfactory system.Frontiers in neural circuits · 2024Review
- A new phase model of the spatiotemporal relationships between three circadian oscillators in the brainstem.Scientific reports · 2023Article
- Potential neural substrates underlying circadian and olfactory disruptions in preclinical Alzheimer's disease.Frontiers in neuroscience · 2023Review
- Review
- Impact of Targeted Deletion of the Circadian Clock Gene Bmal1 in Excitatory Forebrain Neurons on Adult Neurogenesis and Olfactory Function.International journal of molecular sciences · 2020Article
- Circadian regulation of membrane physiology in neural oscillators throughout the brain.The European journal of neuroscience · 2020Review
- Illuminating and Sniffing Out the Neuromodulatory Roles of Dopamine in the Retina and Olfactory Bulb.Frontiers in cellular neuroscience · 2020Review
- Deficiency of the clock gene Bmal1 affects neural progenitor cell migration.Brain structure & function · 2019Article
- Cardinal Epigenetic Role of non-coding Regulatory RNAs in Circadian Rhythm.Molecular neurobiology · 2018Review
- Constant Light Desynchronizes Olfactory versus Object and Visuospatial Recognition Memory Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Dopamine: A Modulator of Circadian Rhythms in the Central Nervous System.Frontiers in cellular neuroscience · 2017Review
- Circadian Plasticity of Mammalian Inhibitory Interneurons.Neural plasticity · 2017Review
- Participation of the Olfactory Bulb in Circadian Organization during Early Postnatal Life in Rabbits.PloS one · 2016Article
- Development of circadian oscillators in neurosphere cultures during adult neurogenesis.PloS one · 2015Article
- Molecular clock regulates daily α1-2-fucosylation of the neural cell adhesion molecule (NCAM) within mouse secondary olfactory neurons.The Journal of biological chemistry · 2014Article
- Vasoactive intestinal polypeptide mediates circadian rhythms in mammalian olfactory bulb and olfaction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Melatonin in the mammalian olfactory bulb.Neuroscience · 2014Article
- The role of nitric oxide in memory is modulated by diurnal time.Frontiers in systems neuroscience · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The suprachiasmatic nucleus (SCN) regulates a wide range of daily behaviors and has been described as the master circadian pacemaker. The role of daily rhythmicity in other tissues, however, is unknown. We hypothesized that circadian changes in olfactory discrimination depend on a genetic circadian oscillator outside the SCN. We developed an automated assay to monitor olfactory discrimination in individual mice throughout the day. We found olfactory sensitivity increased approximately 6-fold from a minimum during the day to a peak in the early night. This circadian rhythm was maintained in SCN-lesioned mice and mice deficient for the Npas2 gene but was lost in mice lacking Bmal1 or both Per1 and Per2 genes. We conclude that daily rhythms in olfactory sensitivity depend on the expression of canonical clock genes. Olfaction is, thus, the first circadian behavior that is not based on locomotor activity and does not require the SCN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.