ArticleProceedings of the National Academy of Sciences of the United States of America2012
Novelty exposure overcomes foot shock-induced spatial-memory impairment by processes of synaptic-tagging in rats.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
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- Amygdala stimulation transforms short-term memory into remote memory by persistent activation of atypical protein kinase C in the anterior cingulate cortex.Neuroscience · 2025Article
- Memory Reconsolidation Updating in Substance Addiction: Applications, Mechanisms, and Future Prospects for Clinical Therapeutics.Neuroscience bulletin · 2025Review
- Memory persistence enhancement by post-learning moderate exercise requires de novo protein synthesis in the dorsal hippocampus.PloS one · 2025Article
- A behavioral tagging account of kinase contribution to memory formation after spaced aversive training.iScience · 2023Article
- Tag and capture: how salient experiences target and rescue nearby events in memory.Trends in cognitive sciences · 2022Review
- Behavioral and Cellular Tagging in Young and in Early Cognitive Aging.Frontiers in aging neuroscience · 2022Article
- Behavioral tagging underlies memory reconsolidation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Novelty enhances memory persistence and remediates propranolol-induced deficit via reconsolidation.Neuropharmacology · 2018Article
- Tyrosine Hydroxylase, Vesicular Monoamine Transporter and Dopamine Transporter mRNA Expression in Nigrostriatal Tissue of Rats with Pedunculopontine Neurotoxic Lesion.Behavioral sciences (Basel, Switzerland) · 2018Article
- Novelty during a late postacquisition time window attenuates the persistence of fear memory.Scientific reports · 2016Article
- Role of hippocampal β-adrenergic and glucocorticoid receptors in the novelty-induced enhancement of fear extinction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Facilitation of fear extinction by novelty depends on dopamine acting on D1-subtype dopamine receptors in hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Extinction learning, which consists of the inhibition of retrieval, can be learned without retrieval.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis.Neural plasticity · 2015Review
- Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage.Neural plasticity · 2015Article
- Hippocampal molecular mechanisms involved in the enhancement of fear extinction caused by exposure to novelty.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The role of rewarding and novel events in facilitating memory persistence in a separate spatial memory task.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Potent attenuation of context fear by extinction training contiguous with acquisition.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Novelty processing can transform short-term into long-term memory. We propose that this memory-reinforcing effect of novelty could be explained by mechanisms outlined in the "synaptic tagging hypothesis." Initial short-term memory is sustained by a transient plasticity change at activated synapses and sets synaptic tags. These tags are later able to capture and process the plasticity-related proteins (PRPs), which are required to transform a short-term synaptic change into a long-term one. Novelty is involved in inducing the synthesis of PRPs [Moncada D, et al. (2011) Proc Natl Acad Sci USA 108:12937-12936], which are then captured by the tagged synapses, consolidating memory. In contrast to novelty, stress can impair learning, memory, and synaptic plasticity. Here, we address questions as to whether novelty-induced PRPs are able to prevent the loss of memory caused by stress and if the latter would not interact with the tag-setting process. We used water-maze (WM) training as a spatial learning paradigm to test our hypothesis. Stress was induced by a strong foot shock (FS; 5 × 1 mA, 2 s) applied 5 min after WM training. Our data show that FS reduced long-term but not short-term memory in the WM paradigm. This negative effect on memory consolidation was time- and training-dependent. Interestingly, novelty exposure prevented the stress-induced memory loss of the spatial task and increased BDNF and Arc expression. This rescuing effect was blocked by anisomycin, suggesting that WM-tagged synapses were not reset by FS and were thus able to capture the novelty-induced PRPs, re-establishing FS-impaired long-term memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.