ArticlemBio2012
Leukocyte inflammatory responses provoked by pneumococcal sialidase.
Article in mBio, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 59 citations in OpenAlex.
- Montelukast treatsMicrobiology spectrum · 2025Article
- Cerebrospinal fluid cytokines and chemokines exhibit distinct profiles in bacterial meningitis and viral meningitis.Experimental and therapeutic medicine · 2023Article
- Altered sialidase expression in human myeloid cells undergoing apoptosis and differentiation.Scientific reports · 2022Article
- Studying the Interaction of Neutrophils and Glaesserella Parasuis Indicates a Serotype Independent Benefit from Degradation of NETs.Pathogens (Basel, Switzerland) · 2022Article
- Increase of intestinal bacterial sialidase activity exacerbates acute colitis in mice.Frontiers in molecular biosciences · 2022Article
- Cytokine response in cerebrospinal fluid of meningitis patients and outcome associated with pneumococcal serotype.Scientific reports · 2021Article
- Vaginal sialoglycan foraging by Gardnerella vaginalis: mucus barriers as a meal for unwelcome guests?Glycobiology · 2021Review
- Sialidase ofInfection and immunity · 2021Article
- Editorial: Host-Pathogen Interactions During Pneumococcal Infection.Frontiers in cellular and infection microbiology · 2021Article
- Novel Virulence Role of Pneumococcal NanA in Host Inflammation and Cell Death Through the Activation of Inflammasome and the Caspase Pathway.Frontiers in cellular and infection microbiology · 2021Article
- Iminosugar idoBR1 Isolated from CucumberACS omega · 2020Article
- Sialic acid-binding immunoglobulin-like lectins (Siglecs) detect self-associated molecular patterns to regulate immune responses.Cellular and molecular life sciences : CMLS · 2020Review
- Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages.Journal of innate immunity · 2020Article
- Role of BgaA as a Pneumococcal Virulence Factor Elucidated by Molecular Evolutionary Analysis.Frontiers in microbiology · 2020Article
- Identification and characterization of NanH2 and NanH3, enzymes responsible for sialidase activity in the vaginal bacteriumThe Journal of biological chemistry · 2019Article
- Article
- Competence-induced protein Ccs4 facilitates pneumococcal invasion into brain tissue and virulence in meningitis.Virulence · 2018Article
- Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model.Scientific reports · 2017Article
- Pneumococcal neuraminidase activates TGF-β signalling.Microbiology (Reading, England) · 2017Article
- Streptococcus pneumoniae Senses a Human-like Sialic Acid Profile via the Response Regulator CiaR.Cell host & microbe · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cell surface expression of sialic acid has been reported to decrease during immune cell activation, but the significance and regulation of this phenomenon are still being investigated. The major human bacterial pathogen Streptococcus pneumoniae causes pneumonia, sepsis and meningitis, often accompanied by strong inflammatory responses. S. pneumoniae expresses a sialidase (NanA) that contributes to mucosal colonization, platelet clearance, and blood-brain barrier penetration. Using wild-type and isogenic NanA-deficient mutant strains, we showed that S. pneumoniae NanA can desialylate the surface of human THP-1 monocytes, leading to increased ERK phosphorylation, NF-κB activation, and proinflammatory cytokine release. S. pneumoniae NanA expression also stimulates interleukin-8 release and extracellular trap formation from human neutrophils. A mechanistic contribution of unmasking of inhibitory Siglec-5 from cis sialic acid interactions to the proinflammatory effect of NanA is suggested by decreased SHP-2 recruitment to the Siglec-5 intracellular domain and RNA interference studies. Finally, NanA increased production of proinflammatory cytokines in a murine intranasal challenge model of S. pneumoniae pneumonia.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.