ReviewCell stress & chaperones2012
Proteotoxic stress and circulating cell stress proteins in the cardiovascular diseases.
Review in Cell stress & chaperones, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- The Role of Extracellular Heat Shock Proteins in Cardiovascular Diseases.Biomedicines · 2023Review
- Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities.MedComm · 2022Review
- Host cell stress response as a predictor of COVID-19 infectivity and disease progression.Frontiers in molecular biosciences · 2022Review
- Effect of nonsurgical periodontal therapy on haematological parameters in grades B and C periodontitis: an exploratory analysis.Clinical oral investigations · 2020Article
- Promising Scaffold-Free Approaches in Translational Dentistry.International journal of environmental research and public health · 2020Review
- Cell-surface HSP70 associates with thrombomodulin in endothelial cells.Cell stress & chaperones · 2019Article
- Association between circulating levels of heat-shock protein 27 and aggressive periodontitis.Cell stress & chaperones · 2018Article
- Golgi-independent routes support protein disulfide isomerase externalization in vascular smooth muscle cells.Redox biology · 2017Article
- Characterization of a natural mouse monoclonal antibody recognizing epitopes shared by oxidized low-density lipoprotein and chaperonin 60 of Aggregatibacter actinomycetemcomitans.Immunologic research · 2016Article
- Contesting the dogma of an age-related heat shock response impairment: implications for cardiac-specific age-related disorders.Human molecular genetics · 2014Article
- Nox NADPH oxidases and the endoplasmic reticulum.Antioxidants & redox signaling · 2014Review
- The physiological roles of apolipoprotein J/clusterin in metabolic and cardiovascular diseases.Reviews in endocrine & metabolic disorders · 2014Review
- Plasma heat shock protein 27 is associated with coronary artery disease, abdominal aortic aneurysm and peripheral artery disease.SpringerPlus · 2014Article
- Monocyte cytokine synthesis in response to extracellular cell stress proteins suggests these proteins exhibit network behaviour.Cell stress & chaperones · 2014Article
- Do reciprocal interactions between cell stress proteins and cytokines create a new intra-/extra-cellular signalling nexus?Cell stress & chaperones · 2013Article
- Extracellular heat shock proteins: a new location, a new function.Shock (Augusta, Ga.) · 2013Review
- Heat shock protein production and immunity and altered fetal development in diabetic pregnant rats.Cell stress & chaperones · 2013Article
- Hsp27 as a marker of cell damage in children on chronic dialysis.Cell stress & chaperones · 2012Article
- Pathology-dependent effects linked to small heat shock proteins expression: an update.Scientifica · 2012Review
- Impact of exercise and metabolic disorders on heat shock proteins and vascular inflammation.Autoimmune diseases · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The cardiovasculature is one of the major body systems and probably the one most exposed to stress. There is clear evidence that increasing levels of cell stress proteins within the heart is cardioprotective. In addition, there is rapidly emerging evidence that secreted cell stress proteins play a role in the function of the cardiovascular tissues. Those secreted proteins have three potential functions: (1) as normal homeostatic cardiovascular signals (e.g. protein disulphide isomerase); (2) as anti-inflammatory molecules, which are able to inhibit cardiovascular pathology (e.g. Hsp27); and (iii) as pro-inflammatory signals that can induce and promote cardiovascular pathology (e.g. Hsp60). As all of these various proteins may be released-at different rates-and in different cardiovascular diseases-we need to consider the cohort of potential secreted cell stress proteins as a dynamic system (network) that can aid and/or damage the equally dynamic cardiovascular system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.