ReviewThe EMBO journal2012
The dark sides of capillary morphogenesis gene 2.
Review in The EMBO journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 84 citations in OpenAlex.
- Dynamic S-acylation controls CMG2 maturation extracellular matrix regulation and anthrax toxin susceptibility in vivo.Nature communications · 2026Article
- Identification and structural characterization of anthrax toxin receptor 2 as the Clostridium perfringens NetF receptor.Nature communications · 2026Article
- Genetic Insights Into Hyaline Fibromatosis Syndrome: A Case Report of an ANTXR2 Mutation Featuring a Rare Variant c.697+1G>A.Clinical case reports · 2025Article
- Investigating the Influence ofGenes · 2024Article
- Multisystemic Manifestations of Hyaline Fibromatosis Syndrome: Implications for Diagnosis and Management.Cureus · 2023Article
- AB Toxins as High-Affinity Ligands for Cell Targeting in Cancer Therapy.International journal of molecular sciences · 2023Review
- Prognostic value analysis of cholesterol and cholesterol homeostasis related genes in breast cancer by Mendelian randomization and multi-omics machine learning.Frontiers in oncology · 2023Article
- Hyaline fibromatosis syndrome with a novel 4.41-kb deletion in ANTXR2 gene: A case report and literature review.Molecular genetics & genomic medicine · 2022Review
- Hyaline fibromatosis syndrome: a case presenting with gingival enlargement as the only clinical manifestation and a report of two new mutations in the ANTXR2 gene.BMC oral health · 2021Article
- Enhanced Collagen Deposition in the Duodenum of Patients with Hyaline Fibromatosis Syndrome and Protein Losing Enteropathy.International journal of molecular sciences · 2020Article
- Clinical aspects of Hyaline Fibromatosis Syndrome and identification of a novel mutation.Molecular genetics & genomic medicine · 2020Article
- Genetic, clinical and biochemical characterization of a large cohort of patients with hyaline fibromatosis syndrome.Orphanet journal of rare diseases · 2019Article
- Targeting Anthrax Toxin Receptor 2 Ameliorates Endometriosis Progression.Theranostics · 2019Article
- Converging physiological roles of the anthrax toxin receptors.F1000Research · 2019Review
- TEM8 functions as a receptor for uPA and mediates uPA-stimulated EGFR phosphorylation.Cell communication and signaling : CCS · 2018Article
- Capillary morphogenesis gene 2 maintains gastric cancer stem-like cell phenotype by activating a Wnt/β-catenin pathway.Oncogene · 2018Article
- The genetic basis of hyaline fibromatosis syndrome in patients from a consanguineous background: a case series.BMC medical genetics · 2018Article
- Protein-losing enteropathy and joint contractures caused by a novel homozygous ANTXR2 mutation.Advances in genomics and genetics · 2018Article
- A pivotal role for a conserved bulky residue at the α1-helix of the αI integrin domain in ligand binding.The Journal of biological chemistry · 2017Article
- CMG2 Expression Is an Independent Prognostic Factor for Soft Tissue Sarcoma Patients.International journal of molecular sciences · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capillary morphogenesis gene 2 (CMG2) is a type I membrane protein involved in the homeostasis of the extracellular matrix. While it shares interesting similarities with integrins, its exact molecular role is unknown. The interest and knowledge about CMG2 largely stems from the fact that it is involved in two diseases, one infectious and one genetic. CMG2 is the main receptor of the anthrax toxin, and knocking out this gene in mice renders them insensitive to infection with Bacillus anthracis spores. On the other hand, mutations in CMG2 lead to a rare but severe autosomal recessive disorder in humans called Hyaline Fibromatosis Syndrome (HFS). We will here review what is known about the structure of CMG2 and its ability to mediate anthrax toxin entry into cell. We will then describe the limited knowledge available concerning the physiological role of CMG2. Finally, we will describe HFS and the consequences of HFS-associated mutations in CMG2 at the molecular and cellular level.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.