ArticleJournal of molecular neuroscience : MN2012
Expression of functional γ-aminobutyric acid type A receptors in Schwann-like adult stem cells.
Article in Journal of molecular neuroscience : MN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Progesterone exerts a neuroprotective action in a Parkinson's disease human cell model through membrane progesterone receptor α (mPRα/PAQR7).Frontiers in endocrinology · 2023Article
- Membrane Progesterone Receptor α (mPRα/PAQR7) Promotes Survival and Neurite Outgrowth of Human Neuronal Cells by a Direct Action and Through Schwann Cell-like Stem Cells.Journal of molecular neuroscience : MN · 2022Article
- Review
- Muscarinic receptors modulate Nerve Growth Factor production in rat Schwann-like adipose-derived stem cells and in Schwann cells.Scientific reports · 2020Article
- Expression and Function of GABA Receptors in Myelinating Cells.Frontiers in cellular neuroscience · 2020Article
- GABA-B1 Receptor-Null Schwann Cells Exhibit Compromised In Vitro Myelination.Molecular neurobiology · 2019Article
- M2 receptors activation modulates cell growth, migration and differentiation of rat Schwann-like adipose-derived stem cells.Cell death discovery · 2019Article
- Improving the glial differentiation of human Schwann-like adipose-derived stem cells with graphene oxide substrates.Interface focus · 2018Article
- The regenerative role of adipose-derived stem cells (ADSC) in plastic and reconstructive surgery.International wound journal · 2017Review
- Human Schwann-like cells derived from adipose-derived mesenchymal stem cells rapidly de-differentiate in the absence of stimulating medium.The European journal of neuroscience · 2016Article
- Adipose derived stem cells and nerve regeneration.Neural regeneration research · 2014Review
- Differentiation of adipose-derived stem cells into Schwann cell phenotype induces expression of P2X receptors that control cell death.Cell death & disease · 2013Article
- Postnatal development, maturation and aging in the mouse cochlea and their effects on hair cell regeneration.Hearing research · 2013Review
- Baclofen modulates the expression and release of neurotrophins in schwann-like adipose stem cells.Journal of molecular neuroscience : MN · 2013Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
γ-Aminobutyric acid (GABA) receptors are present in peripheral and central glia and modulate important physiological parameters of glial cells. Schwann cells (SC), the peripheral nervous system glial cells, play essential roles in nerve regeneration, but they are unsuitable for bioengineering of nerve repair. Increasing interest has been focused on adult stem cells derived from bone marrow (BM-MSC) or adipose tissue (ASC), which can be differentiated into SC-like phenotype and used as SC replacements. SC-like adult stem cells express GABA-B receptors that can modulate their proliferation. The aim of this study was to investigate GABA-A receptors functional expression in differentiated stem cells. BM-MSC and ASC were found to express GABA-A α2 and β3, but not β1 mRNA transcripts. Protein expression levels of GABA-A α2 and β3 receptors were upregulated following SC-like differentiation as shown by Western blot studies. GABA-A receptor stimulation with muscimol increased the proliferation rate of SC, differentiated BM-MSC and differentiated ASC. In conclusion, GABA-A α2 and β3 receptor subunits are present in BM-MSC and ASC and upregulated following glial differentiation. GABA-A subunits in differentiated stem cells and SC assemble in functional receptors modulating cell proliferation. Functional GABA-A and GABA-B receptors represent a possible pharmacological target to modulate SC-like stem cells physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.