SynthesisInternational journal of colorectal disease2012
Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis.
Synthesis in International journal of colorectal disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Meta-analysis of the association between NQO1 Pro187Ser polymorphism and colorectal cancer in Asians.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Association between NAD(P)H:quinone oxidoreductase 1 rs1800566 polymorphism and risk of bladder cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- NQO1 as a predictor of response to adjuvant GemCap treatment for pancreatic cancer.Journal of the National Cancer Institute · 2026Article
- The Absence of Association Between NQO1 rs1800566 Polymorphism and Promoter Methylation With the Risk of Preeclampsia.Oxidative medicine and cellular longevity · 2025Article
- Research on the effects of rs1800566 C/T polymorphism of NAD(P)H quinone oxidoreductase 1 gene on cancer risk involves analysis of 43,736 cancer cases and 56,173 controls.Frontiers in oncology · 2022Article
- The Analysis of NADPH Quinone Reductase 1 (NQO1) Polymorphism in Polish Patients with Colorectal Cancer.Biomolecules · 2021Article
- The diverse functionality of NQO1 and its roles in redox control.Redox biology · 2021Review
- Evaluating the predictive value of genetic risk score in colorectal cancer among Chinese Han population.Journal of human genetics · 2020Article
- Genotype-Environment Interaction Analysis of NQO1, CYP2E1, and NAT2 Polymorphisms and the Risk of Childhood Acute Lymphoblastic Leukemia: A Report From the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia.Frontiers in oncology · 2020Article
- The Influence of Genetic Variability on the Risk of Developing Malignant Mesothelioma.Radiology and oncology · 2018Article
- NQO1 C609T polymorphism and colorectal cancer susceptibility: a meta-analysis.Archives of medical science : AMS · 2014Review
- Genetic polymorphism 609C>T in NAD(P)H:quinone oxidoreductase 1 enhances the risk of proximal colon cancer.Journal of human genetics · 2014Article
- Comparison and validation of genomic predictors for anticancer drug sensitivity.Journal of the American Medical Informatics Association : JAMIAArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionNAD(P)H:quinone oxidoreductase 1 (NQO1) rs1800566 polymorphism is found to have a lower enzymatic activity, which may result in increased incidence of several kinds of carcinomas including colorectal cancer. Results from published studies on the association of NQO1 rs1800566 genetic polymorphism with the risk of colorectal cancer are inconsistent. We performed a meta-analysis to summarize the possible association. MATERIALS AND
methodsAll eligible published studies were searched from PubMed and Elsevier ScienceDirect. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were analyzed for additive, dominant, and recessive models to assess the association using fixed- or random-effect model.
resultsWe identified 12 case-control studies that include 5,525 cases and 6,272 controls for the present meta-analysis. Significant associations between NQO1 rs1800566 genetic polymorphism and risk of colorectal cancer were observed in additive (OR = 1.09, 95% CI = 1.02-1.16, p = 0.009) and dominant models (OR = 1.12, 95% CI = 1.04-1.21, p = 0.004 for TT + CT vs. CC). Moreover, in the subgroup analysis based on ethnicity, significant associations were observed in Caucasians but not in Asians.
conclusionsThis meta-analysis provided evidence that NQO1 rs1800566 genetic polymorphism was associated with increased risk of colorectal cancer and that the T allele probably acts as an important risk factor.
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