ArticleCell cycle (Georgetown, Tex.)2012
Aging reverses the role of the transient receptor potential vanilloid-1 channel in systemic inflammation from anti-inflammatory to proinflammatory.
Article in Cell cycle (Georgetown, Tex.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Peritoneal delivery of capsinoids, nonpungent TRPV1 agonists, induces mild hypothermia in conscious mice through TRPV1 activation of visceral vagal afferents.Scientific reports · 2025Article
- The Role of TRP Channels in Sepsis and Colitis.International journal of molecular sciences · 2024Review
- Endocannabinoid System Components of the Female Mouse Reproductive Tract Are Modulated during Reproductive Aging.International journal of molecular sciences · 2023Article
- The neural pathway of the hyperthermic response to antagonists of the transient receptor potential vanilloid-1 channel.Temperature (Austin, Tex.) · 2023Article
- Research progress on evodiamine, a bioactive alkaloid ofExperimental and therapeutic medicine · 2021Review
- TRPV1: Role in Skin and Skin Diseases and Potential Target for Improving Wound Healing.International journal of molecular sciences · 2021Review
- Innate Receptors Expression by Lung Nociceptors: Impact on COVID-19 and Aging.Frontiers in immunology · 2021Review
- Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19.Frontiers in medicine · 2021Review
- Aging, hormones and receptors.Physiological research · 2020Review
- Ageing and genetic background influence anaesthetic effects in a D. melanogaster model of blunt trauma with brain injuryBritish journal of anaesthesia · 2020Article
- The role of afferent pulmonary innervation in ARDS associated with COVID-19 and potential use of resiniferatoxin to improve prognosis: A review.Medicine in drug discovery · 2020Review
- TRPV1 Contributes to Cerebral Malaria Severity and Mortality by Regulating Brain Inflammation.Oxidative medicine and cellular longevity · 2019Article
- Body Temperature Measurements for Metabolic Phenotyping in Mice.Frontiers in physiology · 2017Article
- Neuronal TRPV1 activation regulates alveolar bone resorption by suppressing osteoclastogenesis via CGRP.Scientific reports · 2016Article
- "TRP inflammation" relationship in cardiovascular system.Seminars in immunopathology · 2016Review
- Involvement of the TRPV1 channel in the modulation of spontaneous locomotor activity, physical performance and physical exercise-induced physiological responses.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Review
- Physical exercise-induced changes in the core body temperature of mice depend more on ambient temperature than on exercise protocol or intensity.International journal of biometeorology · 2014Article
- Association between the increase in brain temperature and physical performance at different exercise intensities and protocols in a temperate environment.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
- The genetic ablation or pharmacological inhibition of TRPV1 signalling is beneficial for the restoration of quiescent osteoclast activity in ovariectomized mice.British journal of pharmacology · 2014Article
- Absence of transient receptor potential vanilloid-1 accelerates stress-induced axonopathy in the optic projection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Studies in young rodents have shown that the transient receptor potential vanilloid-1 (TRPV1) channel plays a suppressive role in the systemic inflammatory response syndrome (SIRS) by inhibiting production of tumor necrosis factor (TNF)α and possibly by other mechanisms. We asked whether the anti-inflammatory role of TRPV1 changes with age. First, we studied the effect of AMG517, a selective and potent TRPV1 antagonist, on aseptic, lipopolysaccharide (LPS)-induced SIRS in young (12 wk) mice. In agreement with previous studies, AMG517 increased LPS-induced mortality in the young. We then studied the effects of TRPV1 antagonism (AMG517 or genetic deletion of TRPV1) on SIRS in middle-aged (43-44 wk) mice. Both types of TRPV1 antagonism delayed and decreased LPS-induced mortality, indicating a reversal of the anti-inflammatory role of TRPV1 with aging. In addition, deletion of TRPV1 decreased the serum TNFα response to LPS, suggesting that the suppressive control of TRPV1 on TNFα production is also reversed with aging. In contrast to aseptic SIRS, polymicrobial sepsis (induced by cecal ligation and puncture) caused accelerated mortality in aged TRPV1-deficient mice as compared with wild-type littermates. The recovery of TRPV1-deficient mice from hypothermia associated with the cecal ligation and puncture procedure was delayed. Hence, the reversal of the anti-inflammatory role of TRPV1 found in the aged and their decreased systemic inflammatory response are coupled with suppressed defense against microbial infection. These results caution that TRPV1 antagonists, widely viewed as new-generation painkillers, may decrease the resistance of older patients to infection and sepsis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.