ArticleBMJ (Clinical research ed.)2012
Publication of NIH funded trials registered in ClinicalTrials.gov: cross sectional analysis.
Article in BMJ (Clinical research ed.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 186 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
186 citing papers in PubMed, 13 syntheses or guidelines pooled it.
- Time to publication for results of clinical trials.The Cochrane database of systematic reviews · 2024Pooled it
- An Economic Model for Estimating Trial Costs with an Application to Placebo Surgery Trials.Applied health economics and health policy · 2023Pooled it
- Assessing the magnitude of reporting bias in trials of homeopathy: a cross-sectional study and meta-analysis.BMJ evidence-based medicine · 2022Pooled it
- Unusual Findings in Trials Evaluating Adjuncts to Scaling and Root Planing: Reporting Quality (Part 2).JDR clinical and translational research · 2022Pooled it
- Glycolytic pathway candidate markers in the prognosis of oral squamous cell carcinoma: a systematic review with meta-analysis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Pooled it
- Results of trials assessing transarterial chemoembolization for treating hepatocellular carcinoma are critically underreported.European radiology · 2020Pooled it
- The Current Landscape of Clinical Studies Focusing on Thyroid Cancer: A Comprehensive Analysis of Study Characteristics and Their Publication Status.Frontiers in endocrinology · 2020Pooled it
- Pooled it
- Registration of published randomized trials: a systematic review and meta-analysis.BMC medicine · 2018Pooled it
- A systematic review of the processes used to link clinical trial registrations to their published results.Systematic reviews · 2017Pooled it
- Inadequate use and regulation of interventions against publication bias decreases their effectiveness: a systematic review.Journal of clinical epidemiology · 2015Pooled it
- Pooled it
- Current status ofIndian journal of pharmacologyPooled it
- Impact of sending email reminders of the legal requirement for posting results on ClinicalTrials.gov: cohort embedded pragmatic randomized controlled trial.BMJ (Clinical research ed.) · 2014Trial
- Processes to manage analyses and publications in a phase III multicenter randomized clinical trial.Trials · 2014Trial
- Review
- Letter to the editor on: "Discontinuation and nonpublication of osteosarcoma clinical trials: a cross-sectional analysis of ClinicalTrials.gov data".European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- Article
- Determinants of publication likelihood and timeliness for clinical studies.Journal of clinical and translational science · 2026Article
- Academic Output of Anesthesiology Departments in Canada From 2014 to 2023: A Bibliometric Analysis Study.Cureus · 2025Review
126 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveTo review patterns of publication of clinical trials funded by US National Institutes of Health (NIH) in peer reviewed biomedical journals indexed by Medline.
designCross sectional analysis.
settingClinical trials funded by NIH and registered within ClinicalTrials.gov (clinicaltrials.gov), a trial registry and results database maintained by the US National Library of Medicine, after 30 September 2005 and updated as having been completed by 31 December 2008, allowing at least 30 months for publication after completion of the trial.
main outcome measuresPublication and time to publication in the biomedical literature, as determined through Medline searches, the last of which was performed in June 2011.
resultsAmong 635 clinical trials completed by 31 December 2008, 294 (46%) were published in a peer reviewed biomedical journal, indexed by Medline, within 30 months of trial completion. The median period of follow-up after trial completion was 51 months (25th-75th centiles 40-68 months), and 432 (68%) were published overall. Among published trials, the median time to publication was 23 months (14-36 months). Trials completed in either 2007 or 2008 were more likely to be published within 30 months of study completion compared with trials completed before 2007 (54% (196/366) v 36% (98/269); P<0.001).
conclusionsDespite recent improvement in timely publication, fewer than half of trials funded by NIH are published in a peer reviewed biomedical journal indexed by Medline within 30 months of trial completion. Moreover, after a median of 51 months after trial completion, a third of trials remained unpublished.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.