ArticleThe journal of physical chemistry. B2012
Folding simulations of the A and B domains of protein G.
Article in The journal of physical chemistry. B, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Article
- Simulations of a protein fold switch reveal crowding-induced population shifts driven by disordered regions.Communications chemistry · 2023Article
- RNA Modeling with the Computational Energy Landscape Framework.Methods in molecular biology (Clifton, N.J.) · 2021Article
- A spin-1 representation for dual-funnel energy landscapes.The Journal of chemical physics · 2018Article
- Evidence of Alternative Splicing as a Regulatory Mechanism for Kissr2 in Pejerrey Fish.Frontiers in endocrinology · 2018Article
- Oligomerization of FVFLM peptides and their ability to inhibit beta amyloid peptides aggregation: consideration as a possible model.Physical chemistry chemical physics : PCCP · 2017Article
- Examination of the quality of various force fields and solvation models for the equilibrium simulations of GA88 and GB88.Journal of molecular modeling · 2016Article
- Theoretical Insights into the Biophysics of Protein Bi-stability and Evolutionary Switches.PLoS computational biology · 2016Article
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Authors and funding
2 authors.
Funding
Abstract
We study wild type and mutants of the A and B domain of protein G using all-atom Go-models. Our data substantiate the usefulness of such simulation for probing the folding mechanism of proteins and demonstrate that multifunnel versions of such models also allow probing of more complicated funnel landscapes. In our case, such models reproduce the experimentally observed distributions of the GA98 and GB98 mutants which differ only by one residue but fold into different structures. They also reveal details on the folding mechanism in these two proteins.
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Registered trials
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